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Characteristics and Training of Neural Responding in BPD

BPD神经反应的特点和训练

基本信息

批准号：
206470023
负责人：
Professorin Dr. Gabriele Ende
金额：
--
依托单位：
Abteilung Neuroimaging
依托单位国家：
德国
项目类别：
Clinical Research Units
财政年份：
2011
资助国家：
德国
起止时间：
2010-12-31 至 2018-12-31
项目状态：
已结题

来源：
https://gepris.dfg.de/gepris/projekt/206470023?language=en
关键词：
Characteristics Training Neural Responding BPD

项目摘要

The aim of this project is to develop an fMRI-based neurofeedback procedure that could be used by patients with BPD to reduce negative affect. In the previous funding period, we presented both BPD patients and healthy controls with aversive pictures and used fMRI to identify which brain regions were associated with negative affect processing, as measured by blood-oxygenlevel dependent (BOLD) contrast imaging. In both groups, looking at such pictures was found to produce a sustained BOLD response in the amygdala but not the anterior insula. Subsequently, we implemented a real-time procedure in which participants received continuous fMRI¿based feedback of their amygdala while viewing aversive pictures, and were asked to use that feedback to try to modulate their brain activation. The first part of that study was conducted in healthy subjects, who demonstrated a successful down-regulation of the amygdala response (Paret et al., 2014a). The same protocol was then implemented with BPD patients. The results of that part of the study are still being analyzed, but preliminary findings show a down-regulation of the amygdala response in this population as well. In the next funding period, our first goal is to enhance the effectivity of the neurofeedback training by an optimized feedback presentation and to explore a connectivity-based neurofeedback in a development study (study 1). The study will investigate whether feedback of connectivity is more effective than feedback of the BOLD response from a single brain region. Our second goal is to use the feedback method with the most robust regulation success to conduct a randomized controlled trial (RCT, study 2). Again, BPD patients will undergo fMRI scans while viewing aversive pictures. One group will be randomized to receive neurofeedback during the scans, while another group will receive the same number of scans but no neurofeedback, in order to control for the effects of being in a research environment. Performance on explicit and implicit emotion regulation tasks will be assessed before and after the intervention, and psychometric assessments will be conducted at each training session. In addition, we will extend our investigations to emotional stimuli that have a positive valence, as these appear to be of particular interest in light of findings from IP1. Activation patterns in brain regions of interest will be compared between BPD patients and healthy participants.

该项目的目的是开发一种基于功能磁共振成像的神经反馈程序，可供 BPD 患者用来减少负面影响。在之前的资助期间，我们向边缘性人格障碍患者和健康对照者展示了令人厌恶的图片，并使用功能磁共振成像来识别哪些大脑区域与负面情绪处理相关，通过血氧水平依赖（BOLD）对比成像进行测量。研究发现，两组人看这些图片时，杏仁核都会产生持续的大胆反应，但前岛叶不会产生这种反应。随后，我们实施了一个实时程序，参与者在观看令人厌恶的图片时接收基于功能磁共振成像的杏仁核反馈，并被要求使用该反馈来尝试调节他们的大脑激活。该研究的第一部分是在健康受试者中进行的，他们证明了杏仁核反应的成功下调（Paret 等人，2014a）。然后对 BPD 患者实施相同的方案。这部分研究的结果仍在分析中，但初步结果显示该人群的杏仁核反应也下调。在下一个资助期内，我们的首要目标是通过优化反馈呈现来提高神经反馈训练的有效性，并在开发研究（研究 1）中探索基于连接的神经反馈。该研究将调查连接反馈是否比单个大脑区域的 BOLD 反应反馈更有效。我们的第二个目标是使用监管最成功的反馈方法来进行随机对照试验（RCT，研究2）。同样，BPD 患者会在观看令人厌恶的图片时接受功能磁共振成像扫描。一组将被随机分配在扫描期间接受神经反馈，而另一组将接受相同数量的扫描但没有神经反馈，以控制研究环境中的影响。干预前后将评估显性和隐性情绪调节任务的表现，并在每次培训课程中进行心理测量评估。此外，我们将把我们的调查扩展到具有正效价的情绪刺激，因为根据 IP1 的发现，这些刺激似乎特别令人感兴趣。将比较 BPD 患者和健康参与者大脑感兴趣区域的激活模式。