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Characteristics and Training of Neural Responding in BPD

BPD神经反应的特点和训练

基本信息

批准号：
206470023
负责人：
Professorin Dr. Gabriele Ende
金额：
--
依托单位：
Abteilung Neuroimaging
依托单位国家：
德国
项目类别：
Clinical Research Units
财政年份：
2011
资助国家：
德国
起止时间：
2010-12-31 至 2018-12-31
项目状态：
已结题

来源：
https://gepris.dfg.de/gepris/projekt/206470023?language=en
关键词：
Characteristics Training Neural Responding BPD

项目摘要

The aim of this project is to develop an fMRI-based neurofeedback procedure that could be used by patients with BPD to reduce negative affect. In the previous funding period, we presented both BPD patients and healthy controls with aversive pictures and used fMRI to identify which brain regions were associated with negative affect processing, as measured by blood-oxygenlevel dependent (BOLD) contrast imaging. In both groups, looking at such pictures was found to produce a sustained BOLD response in the amygdala but not the anterior insula. Subsequently, we implemented a real-time procedure in which participants received continuous fMRI¿based feedback of their amygdala while viewing aversive pictures, and were asked to use that feedback to try to modulate their brain activation. The first part of that study was conducted in healthy subjects, who demonstrated a successful down-regulation of the amygdala response (Paret et al., 2014a). The same protocol was then implemented with BPD patients. The results of that part of the study are still being analyzed, but preliminary findings show a down-regulation of the amygdala response in this population as well. In the next funding period, our first goal is to enhance the effectivity of the neurofeedback training by an optimized feedback presentation and to explore a connectivity-based neurofeedback in a development study (study 1). The study will investigate whether feedback of connectivity is more effective than feedback of the BOLD response from a single brain region. Our second goal is to use the feedback method with the most robust regulation success to conduct a randomized controlled trial (RCT, study 2). Again, BPD patients will undergo fMRI scans while viewing aversive pictures. One group will be randomized to receive neurofeedback during the scans, while another group will receive the same number of scans but no neurofeedback, in order to control for the effects of being in a research environment. Performance on explicit and implicit emotion regulation tasks will be assessed before and after the intervention, and psychometric assessments will be conducted at each training session. In addition, we will extend our investigations to emotional stimuli that have a positive valence, as these appear to be of particular interest in light of findings from IP1. Activation patterns in brain regions of interest will be compared between BPD patients and healthy participants.

该项目的目的是开发一种基于fMRI的神经反馈程序，可用于BPD患者减少负面影响。在上一个资助期，我们向BPD患者和健康对照组提供了令人厌恶的图片，并使用功能磁共振成像（fMRI）来确定哪些大脑区域与负面情绪处理相关，通过血氧水平依赖（BOLD）对比成像进行测量。在这两组实验对象中，研究人员发现，看到这些图片时，杏仁核会产生持续的BOLD反应，但前额叶不会。随后，我们实施了一个实时程序，参与者在观看令人厌恶的图片时，连续接收基于功能磁共振成像的杏仁核反馈，并被要求使用该反馈来调节他们的大脑激活。该研究的第一部分是在健康受试者中进行的，这些受试者证明了杏仁核反应的成功下调（Paret et al.，2014年a）。然后对BPD患者实施相同的方案。这部分研究的结果仍在分析中，但初步发现显示，在这一人群中杏仁核反应也下调。在下一个资助期内，我们的第一个目标是通过优化反馈呈现来提高神经反馈训练的有效性，并在发展研究中探索基于连接的神经反馈（研究1）。该研究将调查连接反馈是否比来自单个大脑区域的BOLD反应反馈更有效。我们的第二个目标是使用具有最稳健调节成功的反馈方法来进行随机对照试验（RCT，研究2）。同样，BPD患者将在观看令人厌恶的图片时接受功能磁共振扫描。一组将被随机分配在扫描过程中接受神经反馈，而另一组将接受相同数量的扫描，但没有神经反馈，以控制在研究环境中的影响。在干预前后将评估外显和内隐情绪调节任务的表现，并在每次培训时进行心理测量评估。此外，我们将扩大我们的调查，情绪刺激，有一个积极的效价，因为这些似乎是特别感兴趣的研究结果，从IP1。将在BPD患者和健康参与者之间比较感兴趣的大脑区域的激活模式。