Temporal and spatial contrast phenomena in pain networks (A06)

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We will build upon novel functional MRI (fMRI) pulse sequences to study the network properties underlying spatial and temporal contrast phenomena in pain. We will further improve cortico-spinal fMRI and perform fMRI network studies and behavioral investigations to test for a spinal contribution to temporal (offset analgesia) and spatial contrast (thermal grill illusion; TGI) phenomena. In addition, we will use fMRI to further investigate the observation that the PAG codes a pain derivative signal and how this signal is integrated into the network of other nociceptive areas such as the secondary somatosensory cortex and the anterior insula.