MRI: Acquisition of a Wide Range Particle Spectrometer

该提案要求获得资金，以购置一台大范围粒子光谱仪(WPS)，用于表征大范围(即纳米到微米级)的气溶胶粒子。该装置是用受试者特定的呼吸道模型支持气雾剂吸入实验所必需的。PI使用ScanIP图像处理软件提取了多达8代带有或不带有口腔的呼吸道的3D图像文件，然后由融合沉积成型3D快速成型机创建。型号可供正常和患病的成人患者使用，也可供患病的儿科患者使用。然后，原型被放置在PI的吸入气溶胶动力学实验室的测试室中。除WPS外，所有部件均可用于气流实验，包括振动式小孔气溶胶发生器和冷凝气溶胶发生器。潮气量和呼吸频率可以控制，以模拟久坐和锻炼状态。区域沉积测量将通过用电离水清洗肺模型的相关部分并测量沉积油滴中存在的尿氨酸的量来获得。虽然提案中没有描述，但从用于创建流经原型的流动的相同3D图像文件创建的计算模型将被开发出来，以便与实验结果进行比较。Pi，Sjiae Hyun，博士(机械工程，NCSU，1998)是美世大学工程学副教授和工程研究项目主任，自2003年以来一直在那里工作。2010年，他在美国环保局吸入剂量学研究实验室休了一年假，接受了呼吸系统中吸入气溶胶传输和沉积实验的培训。2011年夏天，他和一名本科生研究助理继续了这项培训。环境保护局的S博士发来了一封强烈的支持信，他们承诺合作并提供建议。

The proposal requests funds to acquire a Wide range Particle Spectrometer ( WPS) for characterizing a wide range (i.e., nano to micron sized ) aerosol particles. The device is needed to support aerosol inhalation experiments with subject specific airway model. The PI has used ScanIP image processing software to extract 3D images files of up to 8 airway generations with or without the oral cavity, which are then created by a fused deposition molding 3D rapid prototyping machine. Models are available for normal and diseased adult patients and for diseased pediatric patient airways. The prototypes are then placed in a testing chamber in the PI's Inhalation Aerosol Dynamics lab. With the exception of the WPS, all components, including a Vibrating Orifice Aerosol Generator and a Condensation Aerosol Generator, are available for the air flow experiments. Tidal volumes and breathing rates can be controlled to mimic sedentary and exercise states. Regional Deposition Measurements will be obtained by washing out pertinent sections of the lung models with ionized water and measuring the amount of uranine that was present in the deposited oil droplets. Though not described in the proposal, computational models created from the same 3D image files used to create the flow through prototypes would be developed for comparison with the experimental results. The PI, Sinjae Hyun, PhD (Mechanical Engineering, NCSU, 1998) is an Associate Prfoessor od Engineering and Director of the Engineering Research Program at Mercer University, where he has been since 2003. In 2010 he took a sabbatical leave at the US EPA Inhalation Dosimetry Study Lab to obtain training for inhalation aerosol transport and deposition experiments in the respiratory system. He and an undergraduate research assistant continued the training in the summer of 2011. A strong letter of support was included from Chong S, Kim, PhD, EPA, who promised collaboration and advice.