Conference: 2012 Protein Transport Across Cell Membranes GRC and GRS-March 10-16, 2012 in Galveston, Texas

会议：2012 年蛋白质跨细胞膜转运 GRC 和 GRS——2012 年 3 月 10-16 日在德克萨斯州加尔维斯顿举行

• 批准号: 1237083
• 负责人: Kenneth Cline
• 金额: $ 0.7万
• 依托单位: Gordon Research Conferences
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-03-15 至 2013-02-28
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1237083&HistoricalAwards=false
• 关键词: Conference; 2012; Protein; Transport; Across

Intellectual Merit:The fourth biennial Protein Transport Across Cell Membranes Gordon Research Conference (GRC) will be held March 11-16 and will be preceded by the first Gordon Research Seminar for this meeting on March 10-11. Together these conferences will focus on mechanisms involved in translocating proteins across or into biological membranes. Elucidation of protein transport mechanisms remains a fundamental objective of modern cell biology as ~30% of all proteins are either transported across or integrated into cellular membranes. Moreover, defects in protein transport result in several human genetic diseases, and infectious microbes use protein transport systems to deliver virulence factors to plants and animals. Protein translocation machineries (translocases) are highly sophisticated nanomachines, comprising multiple receptors, motors, checkpoints, channels and complex regulatory circuits. As such, progress in this field requires an integrated approach that combines diverse methodologies including biochemistry, genetics, x-ray crystallography, cryo-EM, and fluorescence single molecule imaging. This conference is the only regularly scheduled meeting in the US devoted to an in-depth coverage of the protein transport field. It assembles specialists in these varied methodologies to report unpublished data, to evaluatehypotheses, and to generate new theories and approaches. The overall goal of 2012 Protein Transport across Cell Membranes GRC is to stimulate the exchange and vigorous discussion of the frontiers of knowledge and methodology in the protein transport field. This will be accomplished in large part by the judicious selection and recruitment of speakers and discussion leaders, and also by the intense but informal GRC format of the conference. The 2012 conference will begin with an overview session that will inform participants on the range of experimental systems, approaches, and concepts of this field. Other sessions will cover mechanistic aspects of major transport systems (15 to 20 in some eukaryotes; up to 10 in prokaryotes), as well as novel transport systems. This conference will advance knowledge into the workings of these essential and varied protein transport nanomachines. Thirty-five invited speakers and discussion leaders have already accepted, indicating a high level of enthusiasm for this meeting.Broader impacts: The mission of these associated meetings is to provide a forum that both educates experienced researchers and introduces new investigators into the field. The GRC format, which encourages extensive and spirited discussions of unpublished data and ideas, is perfect for these goals. The associated GRS is a rich training environment that will provide postdocs and students the confidence to engage in such discussions. First, GRS participants will receive basic background in the concepts, principles, and mechanisms involved in protein translocation. Second, they will receive feedback on their research, network with their peers and senior investigators, and sharpen their skills in presentation and discussion in a non-intimidating environment. Other mechanisms to integrate young investigators will include selection for GRC short talks and partial support for GRC registration. Female participants made up 38% of the participants at the 2010 conference. The 2012 GRC and GRS will obtain a gender- (and other minority-) balanced program of speakers with preference for speakers and discussion leaders that will include registration support. Together with an international distribution of attendees, the GRC and GRS will provide a rich educational experience that will mentor a diverse new generation of scientists into this and related fields.

学术价值：第四届两年一度的蛋白质跨细胞膜转运戈登研究会议（GRC）将于3月11日至16日举行，并将于3月10日至11日举行第一次戈登研究研讨会。这些会议将集中讨论蛋白质跨生物膜或进入生物膜的转运机制。蛋白质转运机制的阐明仍然是现代细胞生物学的基本目标，因为所有蛋白质的约30%被转运穿过或整合到细胞膜中。此外，蛋白质转运的缺陷导致几种人类遗传疾病，感染性微生物使用蛋白质转运系统将毒力因子传递给植物和动物。蛋白质易位机器（易位酶）是高度复杂的纳米机器，包括多个受体、马达、检查点、通道和复杂的调节电路。因此，在这一领域的进展需要一个综合的方法，结合不同的方法，包括生物化学，遗传学，X射线晶体学，冷冻EM和荧光单分子成像。本次会议是美国唯一一次定期举行的会议，专门深入报道蛋白质转运领域。它汇集了这些不同方法的专家，以报告未发表的数据，评估假设，并产生新的理论和方法。2012年蛋白质跨细胞膜转运GRC的总体目标是促进蛋白质转运领域知识和方法学前沿的交流和积极讨论。这将在很大程度上通过明智地选择和招聘演讲者和讨论领导人以及通过会议的密集但非正式的GRC形式来实现。2012年会议将开始与概述会议，将告知与会者的范围内的实验系统，方法和概念，这一领域。其他会议将涵盖主要运输系统的机械方面（15至20在一些真核生物;多达10在原核生物），以及新的运输系统。这次会议将推进知识到这些基本的和不同的蛋白质运输纳米机器的工作。35位受邀演讲者和讨论负责人已经接受了邀请，这表明了对这次会议的高度热情。更广泛的影响：这些相关会议的使命是提供一个论坛，既教育有经验的研究人员，又介绍新的研究人员进入该领域。GRC格式鼓励对未发表的数据和想法进行广泛而热烈的讨论，非常适合这些目标。相关的GRS是一个丰富的培训环境，将为博士后和学生提供参与此类讨论的信心。首先，GRS参与者将获得蛋白质易位所涉及的概念，原理和机制的基本背景。其次，他们将收到关于他们的研究的反馈，与他们的同行和高级研究人员建立网络，并在非恐吓环境中提高他们的演讲和讨论技能。吸纳年轻调查人员的其他机制将包括选择参加集体研究理事会的简短会谈和部分支持集体研究理事会的登记。在2010年的会议上，女性与会者占与会者的38%。2012年的GRC和GRS将获得一个性别（和其他少数民族）平衡的演讲者计划，优先考虑演讲者和讨论领袖，包括注册支持。连同与会者的国际分布，GRC和GRS将提供丰富的教育经验，将指导多元化的新一代科学家进入这一领域和相关领域。