I-Corps: Optics for Photodynamic Therapy

I-Corps：用于光动力治疗的光学器件

• 批准号: 1236999
• 负责人: Jannick Rolland
• 金额: $ 5万
• 依托单位: University of Rochester
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-03-15 至 2013-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1236999&HistoricalAwards=false
• 关键词: Corps; Optics; Photodynamic; Therapy

This Innovation Corps project proposes technology that will develop a functional handheld prototype to be used in animal studies and in clinical trials for photodynamic therapy (PDT) of pre-cancers of the skin. The bench prototype will address a large area (2 cm x 2 cm) prototype that responds to clinical needs. The PI and her team anticipate that the breakthrough in the illumination delivery offered by the prototype device will enable a targeted treatment of pre-cancerous conditions of the skin with PDT in a dermatology office. The treatment to be offered will be complementary to the current FDA approved treatment for AK that consists of illuminating the whole anatomic area. In addition, the dosimetry calculations of PDT will critically benefit from the known illumination provided. PDT, a minimally invasive procedure, will be a key to lowering the cost of healthcare; by promoting a more effective treatment, increasing patient compliance (which is key to lowering healthcare cost) for early screening and early treatment. If successful, the proposed technology will improve the current skin PDT treatment by making it more effective, ultimately reducing the number of patient visits needed. For oral cancer, the proposed optical devices will make the treatment cheaper, faster, minimally invasive and more comfortable for the patient, by targeting light to the lesion and not requiring any shielding procedure.

该创新团队项目提出的技术将开发一种功能性手持原型，用于动物研究和皮肤癌前病变光动力疗法（PDT）的临床试验。台架原型将解决响应临床需求的大面积（2 cm x 2 cm）原型。 PI和她的团队预计，原型设备提供的照明传递的突破将使皮肤科办公室的PDT能够有针对性地治疗皮肤癌前病变。将提供的治疗将是对目前FDA批准的AK治疗的补充，包括照亮整个解剖区域。此外，PDT的剂量学计算将从所提供的已知照明中获益匪浅。PDT是一种微创手术，将成为降低医疗成本的关键;通过促进更有效的治疗，提高患者对早期筛查和早期治疗的依从性（这是降低医疗成本的关键）。如果成功的话，这项技术将改善目前的皮肤PDT治疗，使其更有效，最终减少所需的患者就诊次数。对于口腔癌，提出的光学设备将使治疗更便宜，更快，微创和更舒适的病人，通过瞄准光病变，而不需要任何屏蔽程序。