Phage Discovery Goes Viral: Engaging All Biology Students in Research

噬菌体发现迅速传播：让所有生物学学生参与研究

• 批准号: 1245778
• 负责人: Kirk Anders
• 金额: $ 12.97万
• 依托单位: Gonzaga University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-04-01 至 2016-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1245778&HistoricalAwards=false
• 关键词: Phage; Discovery; Goes; Viral; Engaging

The purpose of this project is to engage all of the introductory biology students at Gonzaga University (n=350) in a transformative research-based lab course during their freshman year. The project goals are to 1) increase the science competencies of students at all three developmental levels (beginners, intermediate, and advanced), 2) increase the retention rate of underrepresented minorities in the sciences by engaging students early on in research, and 3) inspire other institutions to implement authentic discovery-based research on a large scale in introductory laboratory courses.Because of the growing recognition that research experience in the first year is a critical influence on retention in science, many programs are now offering an alternative introductory lab sequence based on discovering new mycobacteriophages and annotating their genomes) in a two-semester course, the HHMI (Howard Hughes Medical Institute) SEA-PHAGES (Science Education Alliance-Phage Hunters Advancing Genomics and Evolutionary Science) program. Based on the assumption that the gains observed among this select group of students are the kinds of gains all students could experience, the project team has devised several strategies to effectively scale up SEA-PHAGES and make it the introductory biology lab course for 350 students per year. The strategies involve 1) introducing a one-semester Gonzaga Phage Discovery Lab course for all students in the introductory biology class, 2) implementing a Phage Genomics module embedded within the 200-level Genetics Lab course, 3) offering a third course, Advanced Phage Research Lab, for upper division students, and 4) teaching the Phage Discovery Lab course for non-science majors, as well.Intellectual Merit: With this number of students engaged each year, this project is obtaining strong measures of the effectiveness of the one-semester Phage Discovery lab as a research experience for a wide variety of beginning science and non-science majors. Broader Impacts: The outcomes of this project, can increase the science education community's understanding of how best to increase the scientific literacy of all undergraduates. The project is also producing teaching and learning materials adaptable by other institutions.This project is being jointly funded by the Directorate for Biological Sciences and the Directorate for Education and Human Resources, Division of Undergraduate Education as part of their efforts toward support of Vision and Change in Undergraduate Biology Education.

这个项目的目的是从事所有的介绍生物学学生在贡扎加大学（n=350）在一个变革性的研究为基础的实验室课程在他们的大一。 该项目的目标是1）提高学生在所有三个发展水平的科学能力（初级、中级和高级），2）通过让学生尽早参与研究，提高科学领域代表性不足的少数民族的留存率，3）激励其他机构实施真实的发现-在入门实验室课程中进行大规模的研究。由于越来越多的人认识到，第一年的研究经验对科学的保留有着至关重要的影响，许多项目现在提供了一种基于发现新的分枝杆菌噬菌体和注释它们的基因组的替代的介绍性实验室序列），在两个学期的课程中，HHMI（霍华德休斯医学研究所）SEA-PHAGES（科学教育联盟-噬菌体猎人推进基因组学和进化科学）项目。基于这样的假设，即在这一选定的学生群体中观察到的收益是所有学生都可以体验到的收益，项目团队设计了几种策略，以有效地扩大SEA-PHAGES，并使其成为每年350名学生的入门生物实验室课程。 这些策略包括：1）在生物学入门课程中为所有学生引入为期一学期的贡扎加噬菌体发现实验室课程，2）在200级遗传学实验室课程中嵌入噬菌体基因组学模块，3）为高年级学生提供第三门课程，高级噬菌体研究实验室，4）为非科学专业的学生教授噬菌体发现实验室课程。随着每年参与的学生人数的增加，该项目正在获得一个学期的噬菌体发现实验室的有效性的有力措施，作为各种各样的开始科学和非科学专业的研究经验。更广泛的影响：该项目的成果，可以增加科学教育界的理解，如何最好地提高所有本科生的科学素养。 该项目还制作了可供其他机构使用的教学材料，该项目由生物科学理事会和本科教育部教育和人力资源理事会共同资助，作为支持本科生物学教育愿景和变革的努力的一部分。