Multimodal investigation of neuronal circuits involved in execution and inhibition of self determined and externally guided movements in Tourette syndrome

抽动秽语综合征中参与执行和抑制自我决定和外部引导运动的神经元回路的多模式研究

基本信息

项目摘要

Gilles de la Tourette syndrome (GTS) is characterised by motor and phonic tics, i.e. sudden, repetitive, stereotyped movements or phonic productions preceded by an inner urge to move that can transiently be suppressed. An increased sensitivity to external stimuli triggering typical tics and mirror behaviour (echopraxia) are other salient feature of GTS. The presence of urges suggests that cortical areas engaged in decisions to move or not to move, predominantly frontomesial circuits including the supplementary motor area are involved in the generation of tics. Increased responsiveness to certain external stimuli might reflect abnormalities in dorsal premotor-motor circuits. Echopraxia points at dysfunctions in networks responsible for automatic imitative response tendencies, i.e. the human mirror neuron system including the ventral premotor cortex. In the intended projects we will therefore examine the functional neuroanatomy of frontomesial- and premotor-motor circuits in GTS using fMRI, DTI, MEG and TMS. In project 1, task related brain activity (fMRI and MEG), structural connectivity (DTI) and excitability (TMS) will be studied during execution and suppression of self-determined movements engaging frontomesial-motor circuits and responses determined by symbolic visual cues involving dorsal premotor-motor circuits, respectively. In project 2, echophenomena will be studied during observation and execution of simple finger movements and during observation of facial expressions and facial tics using the same methods. We hypothesise that in GTS i) activation in frontomesial networks will be increased, ii) physiological segregation of cortical 3 networks engaged in self generated and externally determined movements, respectively, will be reduced and iii) the human mirror system will be overactive.
抽动秽语综合征(GTS)的特征是运动和语音抽搐,即突然的、重复的、刻板的运动或语音产生,之前是可以暂时抑制的内在运动冲动。对外部刺激的敏感性增加,触发典型的抽搐和镜像行为(echopraxia)是GTS的另一个显著特征。冲动的存在表明,参与决定移动或不移动的皮层区域,主要是包括辅助运动区在内的前内侧回路参与了抽搐的产生。对某些外部刺激的反应性增加可能反映了背侧前运动-运动回路的异常。错用症指向负责自动模仿反应倾向的网络功能障碍,即人类镜像神经元系统,包括腹侧前运动皮层。因此,在预定的项目中,我们将使用fMRI,DTI,MEG和TMS检查GTS中的前内侧和前运动回路的功能神经解剖学。在项目1中,任务相关的脑活动(功能磁共振成像和MEG),结构连接(DTI)和兴奋性(TMS)的执行和抑制过程中的自我决定的运动,涉及前内侧运动回路和响应的符号视觉线索,涉及背侧前运动回路,分别进行了研究。在项目2中,echphenomena将在观察和执行简单的手指运动,并在观察面部表情和面部抽搐使用相同的方法进行研究。我们假设,在GTS中,i)前内侧网络的激活将增加,ii)分别参与自我生成和外部决定运动的皮层3网络的生理隔离将减少,iii)人类镜像系统将过度活跃。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Professor Dr. Alexander Münchau其他文献

Professor Dr. Alexander Münchau的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Professor Dr. Alexander Münchau', 18)}}的其他基金

Modulation of clinical phenomena and event file coding by repetitive transcranial magnetic stimulation
通过重复经颅磁刺激调节临床现象和事件文件编码
  • 批准号:
    396474989
  • 财政年份:
    2018
  • 资助金额:
    --
  • 项目类别:
    Research Units
Coordination Funds
协调基金
  • 批准号:
    396914663
  • 财政年份:
    2018
  • 资助金额:
    --
  • 项目类别:
    Research Units
Intentional inhibition and self-control in Gilles de la Tourette syndrome
吉尔·德拉图雷特综合征的有意抑制和自我控制
  • 批准号:
    150167100
  • 财政年份:
    2010
  • 资助金额:
    --
  • 项目类别:
    Research Grants
Coordination Funds
协调基金
  • 批准号:
    501528065
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
    Research Units

相似海外基金

Characterize neuronal and glial cell-specific vulnerability to proteinopathies in Alzheimer's disease using multimodal single-nuclei genomic and epigenomic approaches
使用多模式单核基因组和表观基因组方法表征阿尔茨海默病中神经元和神经胶质细胞对蛋白质病的特异性脆弱性
  • 批准号:
    10666954
  • 财政年份:
    2023
  • 资助金额:
    --
  • 项目类别:
Multimodal imaging of memory in epilepsy from whole brain networks to local neuronal responses: Implications for surgical decision-making
从全脑网络到局部神经元反应的癫痫记忆多模态成像:对手术决策的影响
  • 批准号:
    10540407
  • 财政年份:
    2021
  • 资助金额:
    --
  • 项目类别:
Multimodal imaging of memory in epilepsy from whole brain networks to local neuronal responses: Implications for surgical decision-making
从全脑网络到局部神经元反应的癫痫记忆多模态成像:对手术决策的影响
  • 批准号:
    10333627
  • 财政年份:
    2021
  • 资助金额:
    --
  • 项目类别:
Discovery of Multimodal Biomarkers for Parkinsonian Syndromes, Their Progression, and Pathological Relevance
帕金森综合征多模式生物标志物的发现、进展和病理相关性
  • 批准号:
    10642967
  • 财政年份:
    2019
  • 资助金额:
    --
  • 项目类别:
Discovery of Multimodal Biomarkers for Parkinsonian Syndromes, Their Progression, and Pathological Relevance
帕金森综合征多模式生物标志物的发现、进展和病理相关性
  • 批准号:
    10439912
  • 财政年份:
    2019
  • 资助金额:
    --
  • 项目类别:
Discovery of Multimodal Biomarkers for Parkinsonian Syndromes, Their Progression, and Pathological Relevance
帕金森综合征多模式生物标志物的发现、进展和病理相关性
  • 批准号:
    10241249
  • 财政年份:
    2019
  • 资助金额:
    --
  • 项目类别:
Discovery of Multimodal Biomarkers for Parkinsonian Syndromes, Their Progression, and Pathological Relevance
帕金森综合征多模式生物标志物的发现、进展和病理相关性
  • 批准号:
    10493489
  • 财政年份:
    2019
  • 资助金额:
    --
  • 项目类别:
Multimodal Optical Imaging of Hyperdynamic Cerebral Responses to Cardiac Arrest and Resuscitation
心脏骤停和复苏的高动力脑反应的多模态光学成像
  • 批准号:
    9376003
  • 财政年份:
    2017
  • 资助金额:
    --
  • 项目类别:
Multimodal Neuroimaging of Alcohol Withdrawal: The Role of Glutamate in Neural Reorganization
酒精戒断的多模式神经影像学:谷氨酸在神经重组中的作用
  • 批准号:
    10092045
  • 财政年份:
    2017
  • 资助金额:
    --
  • 项目类别:
Multimodal Optical Imaging of Hyperdynamic Cerebral Responses to Cardiac Arrest and Resuscitation
心脏骤停和复苏的高动力脑反应的多模态光学成像
  • 批准号:
    9984661
  • 财政年份:
    2017
  • 资助金额:
    --
  • 项目类别:
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了