Coordination Funds

协调基金

• 批准号: 501528065
• 负责人: Professor Dr. Alexander Münchau
• 金额: --
• 依托单位: Institut für Systemische Motorikforschung
• 依托单位国家: 德国
• 项目类别: Research Units
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/501528065?language=en
• 关键词: Coordination; Funds

Gilles de la Tourette syndrome (GTS) is a common multifaceted neuropsychiatric disorder with motorand vocal tics including echo- and coprophenomena as cardinal and defining clinical features. Despitean abundance of neuroscientific studies in children and adults with GTS, no generally acceptedconcept of tics or GTS has emerged. In the first funding period, we examined the suitability of acognitive framework (i.e., the Theory of Event Coding) to conceptualize tics and other associatedphenomena in GTS. We could confirm our major hypothesis that GTS can be characterized by ahyperbinding of perception and action processes and that such alterations are central for theunderstanding of GTS. In the second funding period, we will build on these results and will addressimportant open questions that are related to four major research fields examined in complementaryprojects: (i) We will examine the feasibility to modulate perception-action binding as part of (novel)treatment approaches. (ii) We will examine the question of how binding is modulated in remitting vs.persisting GTS. (iii) We will address what role binding vs. retrieval processes play in perception-actionintegration in patients with GTS. (iv) We will also transfer event files coding mechanisms from thecognitive to the socio-affective domain. In all projects, we will put a special emphasis on theinvestigation of neurophysiological processes underlying the examined dynamics. The secondfunding period is intended to establish the basis for a transfer of the validated cognitive-theoreticalconceptualization of GTS into clinical applications.

抽动秽语综合征（Gilles de la Tourette syndrome， GTS）是一种常见的多面神经精神疾病，以运动和声音抽搐为主要临床特征，包括回声和回声现象。尽管对患有GTS的儿童和成人进行了大量的神经科学研究，但尚未出现普遍接受的抽搐或GTS概念。在第一个资助期，我们研究了认知框架（即事件编码理论）在GTS中将抽搐和其他相关现象概念化的适用性。我们可以证实我们的主要假设，即GTS可以以感知和行动过程的超结合为特征，并且这种改变是理解GTS的核心。在第二个资助期，我们将以这些结果为基础，并将解决与补充项目中研究的四个主要研究领域相关的重要开放性问题：(i)我们将研究作为（新型）治疗方法的一部分调节感知-行动结合的可行性。（ii）我们将研究在缓解和维持GTS中如何调节绑定的问题。（iii）我们将探讨结合过程与检索过程在GTS患者的感知-行动整合中所起的作用。（iv）我们还将把事件文件编码机制从认知领域转移到社会情感领域。在所有的项目中，我们将特别强调对研究动态的神经生理过程的研究。第二个资助期旨在为将GTS的验证认知理论概念化转移到临床应用奠定基础。