SBIR Phase I: Serendipitous Search System Using Lateral Analogy to Match Potential Solutions to Unmet Needs:Feasibility Study Based on Screening Approved Drugs for Potential Repur

SBIR 第一阶段：使用横向类比将潜在解决方案与未满足需求相匹配的偶然搜索系统：基于筛选已批准药物潜在重复性的可行性研究

• 批准号: 1248901
• 负责人: Brian Sager
• 金额: $ 15万
• 依托单位: Leonardo Innovations Inc.
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1248901&HistoricalAwards=false
• 关键词: SBIR; Phase; Serendipitous; Search; System

This Small Business Innovation Research (SBIR) Phase I project is focused on the development of novel methods for ideation and innovation through the discovery of lateral connections in otherwise unconnected knowledge networks. In many fields of human knowledge and activity, a common feature is that information content is expanding at such a rate that finding relevant results to searches for solutions is becoming increasingly difficult. A further problem is that even the high quality material is expanding at such a rate that most disciplines are rapidly forming sub-disciplines. As fields continue to both expand both at the top levels in terms of overall amount of knowledge, and to expand at the more granular levels by fragmentation into ever more numerous subfields, each of which may develop its own journals, conferences and even terminology, impenetrable to the outsider. It's becoming impossible to stay current. Yet much of creativity occurs, and indeed a great many of the world?s great inventions have occurred, precisely at the intersections between different fields. The central objective of this Phase I project will be to determine the utility of a parsable ontology for supporting ideation and innovation by connecting diverse knowledge domains. The broader impact/commercial potential of this project spans multiple fields and markets, including but not limited to pharmaceuticals, medical devices, materials science, semiconductor devices, chemical processing, legal discovery, patent analyses, and financial analytics. In each of these fields, there is often an increase in 'silo-ing' of different knowledge domains, with the development of access and language barriers in between them, presenting clear challenges to academia and industry. As this situation worsens, there is need of ever better ways to organize, translate and present information to users, and to find solutions to users' problems (their 'unmet needs'). What is needed, and not yet offered by any competitor, is an exploration system giving searchers a strong serendipitous element with a maximum likelihood of results having come from a diverse, unexpected, and potentially provocative source. This will break down silos by providing a rapid, relevant means for knowledge-transfer between different disciplines to facilitate the ready spread of awareness of a potential solution from one field to another, fostering interdisciplinary innovation. The initial customer focus will be on particular corporate clients with a heavy investment in R&D activities and a high probability of internal silo-ing of knowledge, such as pharmaceutical companies.

这个小型企业创新研究(SBIR)第一阶段项目的重点是开发新的方法，通过发现原本不相连的知识网络中的横向联系来进行思维和创新。在人类知识和活动的许多领域中，一个共同的特征是信息内容以如此之快的速度增长，以至于找到相关结果来搜索解决方案变得越来越困难。另一个问题是，即使是高质量的材料也在以如此快的速度扩张，以至于大多数学科都在迅速形成子学科。随着领域继续扩大，既在总知识量方面处于最高水平，又在更细粒度的水平上扩大，分成越来越多的子领域，每个子领域都可能发展出自己的期刊、会议甚至术语，外人无法理解。与时俱进正变得越来越不可能。然而，许多创造力都在发生，世界上确实有很多创造力？S伟大的发明就发生在不同领域的交叉点上。这一第一阶段项目的中心目标将是确定可解析本体的效用，通过连接不同的知识域来支持构思和创新。该项目的广泛影响/商业潜力横跨多个领域和市场，包括但不限于制药、医疗设备、材料科学、半导体设备、化学加工、法律发现、专利分析和金融分析。在这些领域中的每一个领域，随着获取途径和语言障碍的发展，不同知识领域的“孤岛”现象往往有所增加，这给学术界和工业界带来了明显的挑战。随着这种情况的恶化，需要更好的方法来组织、翻译和向用户展示信息，并为用户的问题(他们的“未得到满足的需求”)找到解决方案。目前需要的是一种勘探系统，它为搜索者提供了一个强大的偶然性元素，最大可能的结果来自不同的、意想不到的、潜在的挑衅性来源。这将打破孤岛，为不同学科之间的知识转移提供一种快速、相关的手段，以促进对潜在解决方案的认识从一个领域迅速传播到另一个领域，从而促进跨学科创新。最初的客户重点将是特定的企业客户，这些客户在研发活动上投入了大量资金，内部知识很有可能被孤立起来，比如制药公司。