Regionalization of the Parhyale Bodyplan
Parhyale Bodyplan 的区域化
基本信息
- 批准号:1257379
- 负责人:
- 金额:$ 55.7万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Continuing Grant
- 财政年份:2013
- 资助国家:美国
- 起止时间:2013-03-01 至 2018-02-28
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Most animals, including humans, display an obvious organization of specific body parts and organs along the anterior to posterior axis (A-P axis, head to toe for humans), and over the past several decades scientists have discovered a set of genes, known as homeotic genes, which control the placement of organs and appendages along the A-P axis. While these genes were first discovered in fruit flies, they were subsequently identified in all animals and found to play a common role in controlling the development of such varied species as flies, mice, humans, and worms. While the overall functions of these genes are well conserved, changes in where and when these genes are activated can create remarkable changes in body organization. The aim of this research is to understand the role that these genes have played in the evolutionary processes that have generated animal biodiversity. To do this, the investigators will focus on a group of animals that shows the greatest diversity in the organization of their appendages, the crustaceans, which include shrimp, crabs, lobsters, and an emerging model system called Parhyale. Using modern genetic approaches, the investigators will determine the specific roles of individual homeotic genes in Parhyale, and then use comparative methods to determine if changes in the patterns of homeotic gene expression are responsible for the differences between appendage organization in the various species. The research is expected to reveal the specific types of developmental and evolutionary changes that can be mediated by these genes. This research will train students in the laboratory and will be used to illustrate evolutionary principles to K-12 students and local community college students. Broader outreach to the general public will include public lectures and media presentations.
包括人类在内的大多数动物,其特定的身体部位和器官沿着前后轴(A-P轴,对人类来说是从头到脚)有着明显的组织结构。在过去的几十年里,科学家们发现了一组被称为同源异型基因的基因,它们控制着器官和附属物沿着沿着A-P轴的位置。 虽然这些基因最初是在果蝇中发现的,但随后在所有动物中发现了它们,并发现它们在控制苍蝇、小鼠、人类和蠕虫等不同物种的发育中发挥着共同的作用。 虽然这些基因的整体功能是保守的,但这些基因被激活的位置和时间的变化可以在身体组织中产生显着的变化。 这项研究的目的是了解这些基因在产生动物生物多样性的进化过程中所起的作用。 为了做到这一点,研究人员将专注于一组动物,这些动物在其附属物的组织中表现出最大的多样性,甲壳类动物,包括虾,螃蟹,龙虾和一种名为Parhyale的新兴模型系统。 利用现代遗传学方法,研究人员将确定Parhyale中单个同源异型基因的具体作用,然后使用比较方法来确定同源异型基因表达模式的变化是否是不同物种中附属物组织之间差异的原因。 这项研究有望揭示这些基因介导的特定类型的发育和进化变化。 这项研究将在实验室里训练学生,并将用于向K-12学生和当地社区大学的学生说明进化原理。更广泛地与公众接触将包括公开讲座和媒体介绍。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Nipam Patel其他文献
New materials and new methods: Innovative strategies for integrating new material into syllabi
- DOI:
10.1016/j.ydbio.2011.05.047 - 发表时间:
2011-08-01 - 期刊:
- 影响因子:
- 作者:
Nipam Patel;Yolanda P. Cruz;Michael Barresi;Laurie Iten;Scott F. Gilbert - 通讯作者:
Scott F. Gilbert
Mechanisms of Transcriptional Precision in the Drosophila Embryo by Jacques Pierre Bothma A dissertation submitted in partial satisfaction of the requirements for the degree of Doctor of Philosophy
果蝇胚胎转录精确性的机制,作者:Jacques Pierre Bothma 部分满足哲学博士学位要求的论文
- DOI:
- 发表时间:
2013 - 期刊:
- 影响因子:0
- 作者:
Nipam Patel;Jan Liphardt;Jacques P. Bothma;Michael Levine;S. Marqusee - 通讯作者:
S. Marqusee
Elucidating nanostructural organisation and photonic properties of butterfly wing scales using hyperspectral microscopy
使用高光谱显微镜阐明蝴蝶翅膀鳞片的纳米结构组织和光子特性
- DOI:
- 发表时间:
2024 - 期刊:
- 影响因子:0
- 作者:
Anna;P. Pirih;Limin Wang;Nipam Patel;P. Clode;Gerd Schroeder;Bodo Wilts - 通讯作者:
Bodo Wilts
Ecdysozoan Sequencing Proposal
蜕皮动物测序提案
- DOI:
- 发表时间:
2007 - 期刊:
- 影响因子:0
- 作者:
Nipam Patel;D. Rokhsar;M. Telford;G. Budd;M. Akam;A. Chipman;M. Blaxter;Michael Eisen - 通讯作者:
Michael Eisen
Nipam Patel的其他文献
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{{ truncateString('Nipam Patel', 18)}}的其他基金
DISSERTATION RESEARCH: Morphological, genetic, and evolutionary bases for structurally blue scales of Buckeye butterflies
论文研究:七叶树蝴蝶蓝色鳞片结构的形态学、遗传和进化基础
- 批准号:
1601815 - 财政年份:2016
- 资助金额:
$ 55.7万 - 项目类别:
Standard Grant
Meeting: Integrating Evolution, Development, and Genomics (IEDG 2008) Meeting at the University of California-Berkeley, CA, May 28-30, 2008
会议:整合进化、发展和基因组学 (IEDG 2008) 会议于 2008 年 5 月 28-30 日在加利福尼亚州加州大学伯克利分校举行
- 批准号:
0829295 - 财政年份:2008
- 资助金额:
$ 55.7万 - 项目类别:
Standard Grant
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2139765 - 财政年份:2022
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