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Reciprocal regulation between the circadian clock and the iron homeostasis network in Arabidopsis

Reciprocal regulation between the circadian clock and the iron homeostasis network in Arabidopsis
拟南芥生物钟与铁稳态网络之间的相互调节
批准号:
1257722
负责人:
C. Robertson McClung
金额:
$55.53万
依托单位:
依托单位国家:
美国
项目类别:
Continuing Grant
财政年份:
2014
资助国家:
美国
项目状态:
已结题
起止时间:
2014-02-15 至 2018-01-31

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C. Robertson McClungIOS 1257722 Reciprocal regulation between the circadian clock and the iron homeostasis network in ArabidopsisThis project will contribute to understanding the role of circadian regulation of iron homeostasis in plants, which is important for two reasons. First, iron often limits plant growth and agricultural yield. Second, although most people acquire iron from plant sources, plant-based diets are poor sources of iron, and iron deficiency represents the single most common human nutritional disorder, affecting approximately one-half of the world's population. The circadian clock integrates temporal information and coordinates many aspects of biology, including metabolism and responses to stress. Specifically, the plant circadian clock regulates the iron homeostasis gene network and, in turn, iron status modulates clock function. This project should help to shape a temporally integrated picture of iron homeostasis; the goal is to understand the network of genes responsible for integrating information about iron status and orchestrating a coordinated response that is temporally as well as spatially regulated. This should transform efforts towards sustainable improvements of crop yields in terms of plant productivity and nutrient content. The project will test the hypothesis that impaired circadian function adversely affects iron homeostasis and thus contributes to reduced fitness and, in agricultural settings, to reduced yield and reduced nutritional quality of food. Understanding the circadian regulation of iron homeostasis may contribute to crop productivity and to nutritional quality of food, particularly in crops grown over broad latitudinal ranges.This project will implement Genetics teaching modules in middle school classrooms in Vermont and New Hampshire in collaboration with the Montshire Museum of Science. Genetic resources (mutant lines and constructs) will be deposited with the Arabidopsis Biological Resource Center. Molecular data will be deposited in the Gene Expression Omnibus (GEO) database.
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Gordon Research Conference on Plant Molecular Biology: Spatial and Temporal Dynamics in Plant Biology, Holderness, New Hampshire, June 14-19, 2020
  • 批准号:
    2005283
  • 项目类别:
    Standard Grant
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    $1.5万
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    2020
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    Standard Grant
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    2010
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    $307.96万
  • 财政年份:
    2006
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