Reciprocal regulation between the circadian clock and the iron homeostasis network in Arabidopsis

拟南芥生物钟与铁稳态网络的相互调节本项目将有助于了解植物铁稳态的昼夜调节作用，这有两个重要原因。首先，铁通常会限制植物生长和农业产量。第二，尽管大多数人从植物中获取铁，但植物性饮食是铁的不良来源，缺铁是最常见的人类营养失调，影响着世界上大约一半的人口。生物钟整合了时间信息，协调了生物学的许多方面，包括新陈代谢和对压力的反应。具体来说，植物生物钟调节铁稳态基因网络，反过来，铁状态调节生物钟功能。该项目应有助于形成铁体内平衡的时间综合图景；目标是了解负责整合铁状态信息的基因网络，并协调时间和空间调节的协调反应。这应使努力转向在植物生产力和养分含量方面可持续地提高作物产量。该项目将验证这样一种假设，即受损的昼夜节律功能会对铁稳态产生不利影响，从而导致适应性降低，并在农业环境中导致粮食产量下降和营养质量下降。了解铁体内平衡的昼夜节律调节可能有助于作物的生产力和食物的营养质量，特别是在纬度较宽的作物中。该项目将与蒙特希尔科学博物馆合作，在佛蒙特州和新罕布什尔州的中学课堂上实施遗传学教学模块。遗传资源（突变系和构建体）将存放在拟南芥生物资源中心。分子数据将存储在基因表达综合数据库（GEO）中。

C. Robertson McClungIOS 1257722 Reciprocal regulation between the circadian clock and the iron homeostasis network in ArabidopsisThis project will contribute to understanding the role of circadian regulation of iron homeostasis in plants, which is important for two reasons. First, iron often limits plant growth and agricultural yield. Second, although most people acquire iron from plant sources, plant-based diets are poor sources of iron, and iron deficiency represents the single most common human nutritional disorder, affecting approximately one-half of the world's population. The circadian clock integrates temporal information and coordinates many aspects of biology, including metabolism and responses to stress. Specifically, the plant circadian clock regulates the iron homeostasis gene network and, in turn, iron status modulates clock function. This project should help to shape a temporally integrated picture of iron homeostasis; the goal is to understand the network of genes responsible for integrating information about iron status and orchestrating a coordinated response that is temporally as well as spatially regulated. This should transform efforts towards sustainable improvements of crop yields in terms of plant productivity and nutrient content. The project will test the hypothesis that impaired circadian function adversely affects iron homeostasis and thus contributes to reduced fitness and, in agricultural settings, to reduced yield and reduced nutritional quality of food. Understanding the circadian regulation of iron homeostasis may contribute to crop productivity and to nutritional quality of food, particularly in crops grown over broad latitudinal ranges.This project will implement Genetics teaching modules in middle school classrooms in Vermont and New Hampshire in collaboration with the Montshire Museum of Science. Genetic resources (mutant lines and constructs) will be deposited with the Arabidopsis Biological Resource Center. Molecular data will be deposited in the Gene Expression Omnibus (GEO) database.