Reciprocal regulation between the circadian clock and the iron homeostasis network in Arabidopsis

C. Robertson McClungIOS 1257722在植物中昼夜节律钟和铁稳态网络之间的相互调节该项目将有助于理解植物中铁稳态的昼夜节律调节的作用，这有两个原因。首先，铁通常限制植物生长和农业产量。其次，虽然大多数人从植物来源获得铁，但植物性饮食是铁的不良来源，缺铁是最常见的人类营养失调症，影响了世界上大约一半的人口。生物钟整合了时间信息，并协调了生物学的许多方面，包括新陈代谢和对压力的反应。具体而言，植物生物钟调节铁稳态基因网络，反过来，铁状态调节时钟功能。这个项目应该有助于形成一个铁稳态的时间整合图;目标是了解负责整合铁状态信息的基因网络，并协调时间和空间调节的协调反应。这将使努力转向可持续地提高作物产量，包括植物生产力和营养成分。该项目将测试以下假设：昼夜节律功能受损对铁体内平衡产生不利影响，从而导致健康状况下降，在农业环境中，导致产量下降和食物营养质量下降。了解铁内稳态的昼夜节律调节可能有助于作物生产力和食物的营养质量，特别是在广泛的纬度范围内种植的作物。本项目将与蒙特希尔科学博物馆合作，在佛蒙特州和新罕布什尔州的中学教室实施遗传学教学模块。遗传资源（突变株系和构建体）将存放在拟南芥生物资源中心。分子数据将存入基因表达综合数据库（GEO）。

C. Robertson McClungIOS 1257722 Reciprocal regulation between the circadian clock and the iron homeostasis network in ArabidopsisThis project will contribute to understanding the role of circadian regulation of iron homeostasis in plants, which is important for two reasons. First, iron often limits plant growth and agricultural yield. Second, although most people acquire iron from plant sources, plant-based diets are poor sources of iron, and iron deficiency represents the single most common human nutritional disorder, affecting approximately one-half of the world's population. The circadian clock integrates temporal information and coordinates many aspects of biology, including metabolism and responses to stress. Specifically, the plant circadian clock regulates the iron homeostasis gene network and, in turn, iron status modulates clock function. This project should help to shape a temporally integrated picture of iron homeostasis; the goal is to understand the network of genes responsible for integrating information about iron status and orchestrating a coordinated response that is temporally as well as spatially regulated. This should transform efforts towards sustainable improvements of crop yields in terms of plant productivity and nutrient content. The project will test the hypothesis that impaired circadian function adversely affects iron homeostasis and thus contributes to reduced fitness and, in agricultural settings, to reduced yield and reduced nutritional quality of food. Understanding the circadian regulation of iron homeostasis may contribute to crop productivity and to nutritional quality of food, particularly in crops grown over broad latitudinal ranges.This project will implement Genetics teaching modules in middle school classrooms in Vermont and New Hampshire in collaboration with the Montshire Museum of Science. Genetic resources (mutant lines and constructs) will be deposited with the Arabidopsis Biological Resource Center. Molecular data will be deposited in the Gene Expression Omnibus (GEO) database.