Collaborative Research: Modeling and Control of Magnetic Chemotherapy

合作研究：磁化疗的建模和控制

• 批准号: 1261938
• 负责人: Benjamin Shapiro
• 金额: $ 30.17万
• 依托单位: University of Maryland, College Park
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-07-01 至 2016-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1261938&HistoricalAwards=false
• 关键词: Collaborative; Research; Modeling; Control; Magnetic

The objective of this collaborative research award is to improve the delivery of chemotherapy drugs to its target tumors. With existing chemotherapy, it is estimated that less than 0.1 percent of the administered drugs are taken up by the tumor, the remaining 99.9 percent go to healthy tissue and cause severe and life-threatening side-effects. In magnetic drug targeting, chemotherapy can be attached to biocompatible magnetic particles. This allows magnetic control of the drugs - magnets placed outside the patient can potentially be used to focus the therapy to tumors. Doing so is difficult. The human body is complex and it is not yet understood how to actuate the magnets (when to turn them on and off) to best direct the drugs to the tumors. The goal of this project is to develop sophisticated and experimentally-validated tools to better understand how magnetized chemotherapy moves through the body, and based on these to develop methods to optimally actuate the magnets to better direct the chemotherapy to tumors.If successful, the broader impact will be a suite of techniques to improve magnetic drug targeting - potentially moving it from a method that could only focus drugs to single shallow tumors, to one that could access deep tumors as well as small and poorly vascularized metastatic tumors spread throughout the body. This project is a collaborative effort between cancer clinicians, engineers, and mathematicians, and will also serve to bring these fields closer together in major part by training students to work effectively at the intersection of these three areas. High school, undergraduate, and graduate students will be involved in the research, and will interact with doctors, engineers, and mathematicians on a weekly basis.

该合作研究奖的目的是改善化疗药物向其靶向肿瘤的输送。在现有的化疗中，估计只有不到0.1%的药物被肿瘤吸收，其余99.9%进入健康组织并引起严重和危及生命的副作用。在磁性药物靶向中，化疗可以附着在生物相容性磁性颗粒上。这允许药物的磁性控制-放置在患者体外的磁体可以潜在地用于将治疗集中于肿瘤。这样做是困难的。人体是复杂的，目前还不知道如何启动磁铁（何时打开和关闭），以最好地将药物导向肿瘤。该项目的目标是开发复杂的和实验验证的工具，以更好地了解磁化化疗如何在体内移动，并在此基础上开发最佳驱动磁体的方法，以更好地将化疗导向肿瘤。如果成功，更广泛的影响将是一套技术，以提高磁性药物靶向-潜在地将其从一种只能将药物集中到单个浅肿瘤的方法，转移到一种可以进入深部肿瘤以及遍布全身的小的和血管化不良的转移性肿瘤的方法。该项目是癌症临床医生、工程师和数学家之间的合作努力，并且还将通过培训学生在这三个领域的交叉点有效工作，在很大程度上使这些领域更加紧密地联系在一起。高中，本科和研究生将参与研究，并将每周与医生，工程师和数学家互动。