Genetically controlled self-assembly of inorganic-bioorganic hybrid structures: From sponge genes to layered functional materials

无机-生物有机杂化结构的基因控制自组装：从海绵基因到层状功能材料

• 批准号: 210301397
• 负责人: Professor Dr. Wolfgang Tremel
• 金额: --
• 依托单位: Department Chemie
• 依托单位国家: 德国
• 项目类别: Priority Programmes
• 财政年份: 2012
• 资助国家: 德国
• 起止时间: 2011-12-31 至 2013-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/210301397?language=en
• 关键词: Genetically; controlled; self; assembly; inorganic

The proposed project aims at the synthesis materials based on inorganic multicomponent oxides and recombinant silicatein and their evaluation for the fabrication of hierarchically structured tunable hybrid-biomaterials. We propose to utilize recombinant silicatein for the biocatalytic synthesis of binary and multinary (e.g. SnO2, In2O3, BaSnO3, PbTiO3, LaFeO3) oxides and the fabrication of multilayered structures from alternating proteins/oxide layers. Alternatively, Bragg stacks shall be used as synthetic analogues of these multilayer hybrids. Peptides with a specific affinity to various perovskites (e.g. BaSnO3, BaTiO3, BiFeO3, PbTiO3) will be selected by phage display screening. In addition, polymers containing silicatein, perovskite-affine peptides and self-assembling domains based on peptide sequences leading to the formation of interconnected, self-assembled β-sheet fibrils or poly-(-N-isopropyl-acrylamide) (PNIPAM) polymers that form stimulus-responsive polymers undergoing a volume phase transition across a lower critical solution temperature shall be prepared. These novel hybrid polymers will be investigated for their self-assembly properties, their solution behavior such as lower critical solution temperatures, their ability to form gel precipitates and others. In parallel, the potential of the silicatein protein polymers for the nucleation and growth of multimetallic perovskite and perovskite-like materials will be evaluated that possess a wide range of useful electronic, magnetic, and optical properties.

拟议的项目旨在基于无机多组分氧化物和重组硅蛋白的合成材料，并评估其制造层次结构化的可调式杂交生物材料。我们建议利用重组硅蛋白来用于二元和多差的生物催化合成（例如SNO2，In2O3，In2O3，Basno3，PBTIO3，LaFeo3）氧化物，以及通过改变蛋白质/氧化物层来制造多层结构。或者，Bragg堆栈应用作这些多层混合体的合成类似物。具有特定亲和力的肽（例如Basno3，batio3，BifeO3，PBTIO3）将通过噬菌体显示筛选选择。 In addition, polymers containing siliconein, perovskite-affine peptides and self-assembling domains based on peptide sequences leading to the formation of interconnected, self-assembled β-sheet fibrils or poly-(-N-isopropyl-acrylamide) (PNIPAM) polymers that form stimulus-responsive polymers undergoing a volume phase transition across a lower critical solution temperature shall be prepared.这些新型混合聚合物的自组装特性，其溶液行为，例如较低的临界溶液温度，它们形成凝胶沉淀和其他人的能力。同时，将评估硅蛋白蛋白聚合物对多金属钙钛矿和类似钙钛矿的材料的成核和生长的潜力，该材料将具有多种有用的电气，磁性和光学特性。