Planning Grant: I/UCRC for Mid-Infrared MEdical Systems

1266294普林斯顿大学;克莱尔Gmachi拟议中的中心，由普林斯顿大学领导，将专注于开发新的中红外技术的医疗应用。该中心的临床研究合作伙伴是克利夫兰诊所。拟议中的MIMES中心计划建立长期的大学、诊所和工业合作伙伴关系，致力于研究和开发采用中红外光子技术的医疗应用工程系统。目前，在医疗应用中使用特定波长的中红外激光器时，存在未开发的机会。首先，生物和生理化合物，如葡萄糖、溶解的血液气体或蛋白质及其畸形的癌症相关形式在中红外光谱范围内具有特征性光谱特征。其次，呼吸成分作为健康、疾病控制或药物使用监测的生物标志物的重要性正在迅速增加;它们可以通过现在唯一可用的快速时间分辨中红外传感器快速检测。最后，通过使用特定针对蛋白质、脂质或水的波长的高功率激光，可以更安全地和更少地损伤周围组织地凝固、消融和以其他方式操纵特定组织。同样，对于新的诊断技术和技术的需求也很大，这些技术和技术能够实现新的医学研究，并开发新的、快速的和/或非侵入性的诊断工具。该中心将在两个快速发展的前沿研究领域中红外光子学和生物医学工程与诊断学的交叉点上运作，并在长期的大学-临床-工业合作伙伴关系的保护伞下将它们结合在一起。必要的成果是新的生物医学诊断工具，这些工具的开发非常接近工业现实和理解，能够将新发现，知识和原型最快地转化为市场和社会，为所有人提供更好的短期和长期医疗保健。MIMES将主要与对工业研发和工业职业有明确兴趣的研究生和高年级本科生进行研究。这一重点，再加上全面的招聘和指导计划与强大的行业参与将促进发展的多样化，训练有素，具有全球竞争力的毕业生群体的劳动力，准备承担领导在现实世界中，应用，生物医学和光子工程。

1266294 Princeton University; Claire Gmachi The proposed center, led by Princeton University, will focus on developing the medical applications of new mid-infrared technologies. The clinical research partner for the proposed center is the Cleveland Clinic. The proposed center for MIMES plans to form long-term universityclinicindustry partnerships dedicated to the research and development of engineering systems employing mid-infrared photonic technologies for medical applications. As yet un-exploited opportunities present themselves when using mid-infrared lasers at specific wavelengths for medical applications. First, biological and physiological compounds, such as glucose, dissolved blood gases, or proteins and their malformed cancer-implicated forms have characteristic spectroscopic features in the mid-infrared spectral range. Next, breath constituents are rapidly gaining in importance as bio markers for health, disease-control, or drug-use monitoring; they can be detected rapidly by the only-now becoming available fast time-resolved mid-infrared sensors. Finally, specific tissue can be coagulated, ablated, and otherwise manipulated more safely and less damaging to surrounding tissue with the use of high-power lasers at wavelengths specifically targeting proteins, lipids, or water. Similarly, the needs are great for new Diagnostics techniques and technologies that enable new medical research, and develop new, fast and/or non-invasive diagnostics tools. The proposed center will operate at the intersection of two rapidly advancing, cutting-edge research fields mid-infrared photonics and bio-medical engineering and diagnostics and joins them together under the umbrella of long-term universityclinicindustry partnership. The necessary outcomes are new bio-medical diagnostics tools, developed so close to industrial reality and understanding to enable a most speedy translation of the new discoveries, knowledge, and prototypes into the marketplace and society, providing better healthcare in both the short and long-term for all. MIMES will conduct research primarily with graduate students and senior undergraduate students who have clear interests in industrial R&D and careers in industry. This focus, together with a comprehensive recruiting and mentoring plan with strong industry involvement will foster the development of a diverse, superbly trained, and globally competitive group of graduates for a workforce that is ready to assume leadership in real-world, applied, bio-medical and photonic engineering.