SPRF-IBSS: Applying structural equation modeling to populations undergoing economic transition

经济转型正在发展中国家迅速发生，并导致无数的社会，行为和生物变化。这项研究的重点是免疫功能与行为，心理和社区因素的关系。第一个研究问题的重点是身体活动/久坐行为是否是一个中介影响生活方式的不协调（心理社会压力的指标）和免疫功能之间的关系在土著西伯利亚成年人。第二个研究问题是，社区一级的亚马孙土著儿童和成年人市场一体化是否预示着生物结果。第三个研究问题是，社区一级的市场一体化在五年内是否可以预测亚马逊土著儿童和成人的生物结果。智力优势：这些复杂的关系需要先进的生物统计技术来正确分析。该项目的重点是学习结构方程模型（SEM），并将通用的统计方法应用于有关土著人口过渡的生物结果的问题。 研究问题进行了评估，使用的数据从2009年西伯利亚的萨哈（雅库特）成年人的样本和2002-2009年在玻利维亚的Tsimane年度小组调查。将使用SEM路径分析评估身体活动和久坐行为对雅库特成年人生活方式不协调和生物学结局之间关系的中介作用。社区市场一体化和社区市场一体化五年变化对Tsimane生物学结果的影响？成人和儿童将使用多层次的SEM进行评估。这项研究利用多学科技术：1）提供洞察的途径，通过心理社会压力影响免疫功能; 2）推进社区对生物学的影响的理解。研究团队成功地利用了先进的统计训练和生物学的配对，倡导定量方法来衡量经济转型对身体健康的影响。此外，拟议的活动是跨学科的研究借鉴，并在一定程度上说，是在几个领域，包括人类生物学，人类学，社会学，卫生经济学，生理学，人口学和行为ecology.Broader影响相关的问题：实现研究目标和传播的研究结果，以研究人员和当地居民增加了解经济和社会转型对生物成果在发展中国家的影响。它还提高了对人类生物学和生物人类学研究中先进生物统计技术的有用性的认识。此外，该研究金项目在许多不同层面上整合了研究和教育。

Economic transition is occurring rapidly in developing countries and resulting in a myriad of social, behavioral and biologic changes. This research focuses on immune function's relationship to behavioral, psychosocial and community factors. The first research question focuses on whether physical activity/sedentary behavior is a mediating influence on the relationship between lifestyle incongruity (an indicator of psychosocial stress) and immune function in indigenous Siberian adults. The second research question is whether community level market integration in indigenous Amazonian children and adults predictive of biological outcomes. The third research question is whether in community level market integration over a five year period predictive of biological outcomes in indigenous Amazonian children and adults. Intellectual Merit: These complex relationships require advanced bio-statistical techniques to properly analyze. This project focuses on learning structural equation modeling (SEM) and applying the versatile statistical method to questions regarding the biological outcomes of transition in indigenous populations. The research questions are assessed using data from a sample of Sakha (Yakut) adults of Siberia in 2009 and the Tsimane Annual Panel Survey in Bolivia in 2002-2009. The mediating effect of physical activity and sedentary behavior on the relationship between lifestyle incongruity and biological outcomes in Yakut adults will be assessed using SEM path analysis. The influence of community market integration and five year change in community market integration on biological outcomes in Tsimane? adults and children will be assessed using multi-level SEM.This research utilizes multi-disciplinary techniques to: 1) provide insight into the pathways through which psychosocial stress influences immune function; 2) advance understanding of the community influence on biology. The research team succesfully exploits the pairing of advanced statistical training and biology to advocate for quantitative approaches to measuring the effects of economic transition on physical health. Additionally, the proposed activities are interdisciplinary to the extent that the research draws from and speaks to issues that are pertinent within several fields including human biology, anthropology, sociology, health economics, physiology, demography, and behavioral ecology.Broader Impacts:Achieving the research goals and disseminating the findings to researchers and local populations increases understanding of the impacts of economic and social transition on biological outcomes in the developing world. It also increases awareness of the usefulness of advanced biostatistical techniques within human biology and bioanthropology research. In addition, this Fellowship project integrates research and education at many different levels.