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Hemocompatibility of Nitinol Thin Films with TiO surface

TiO 表面镍钛诺薄膜的血液相容性

基本信息

批准号：
1310074
负责人：
Mohanchandra Panduranga
金额：
$ 36万
依托单位：
University of California-Los Angeles
依托单位国家：
美国
项目类别：
Continuing Grant
财政年份：
2013
资助国家：
美国
起止时间：
2013-08-15 至 2017-12-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1310074&HistoricalAwards=false
关键词：
Hemocompatibility Nitinol Thin Films TiO

项目摘要

This award from the Biomaterials program in the Division of Materials Research is to investigators in the School of Engineering and Applied Science working with investigators in the School of Medicine at University of California, Los Angeles. This award is cofunded by the Materials Surface Engineering program in the Division of Civil, Mechanical & Manufacturing Innovation. The major aim of this research is to overcome the classic biological problems encountered with current vascular graft materials such as expandable polytetrafluoroethylene based stents. The scientific goal of this project is in developing a fundamental understanding of the biological responses to thin film Nitinol (TFN) based materials. The TFN contains both a biomimicking Titanium Oxide (TiO) surface and an intelligently designed micro porosity pattern. The investigators hypothesized that a negatively charged TiO surface better mimics the charge structure of the native vascular system as compared to existing graft materials, and thus reducing thrombosis while promoting re-endothelialization. This biomimicking process is further enhanced with intelligently designed micro-pores that promote direct cellular communication between the neointima forming on the lumen side of the device and the underlying native vessel while preventing neointimal hyperplasia. The proposed research represents an interdisciplinary collaboration addressing a significant limitation of covered stents and other vascular graft materials available today. The program includes educational activities to inspire students' (from K-12 to graduate level) interest in science and engineering.This award provides a potential new materials approach to treat a wide range of vascular diseases including peripheral arterial disease, which affects over 10 million Americans. Recently, the use of expandable polytetrafluoroethylene covered stents for treating peripheral arterial disease has increased, but still has a 35% failure rate within 1 year suggesting significant shortcomings with this type of graft material. Three of the primary failure mechanisms are graft thrombosis, edge stenosis and lack of re-endothelialization. To overcome these problems, the researches of this project will use biomimicry and intelligent design to develop a new hemocompatible material. This research project will provide opportunities for a wide range of underrepresented students from K-12 to graduate levels. The K-12 students are encouraged to consider science and engineering studies during outreach presentations at local schools twice a year. The investigators of this project will participate with the Center for Excellence in Engineering and Diversity program at UCLA to provide a diverse group (4-6) of undergraduate students in conducting research on this project for one quarter. Additionally, this project will use a peer mentoring process in a collaborative environment to educate undergraduates on new cutting-edge technologies while encouraging them to consider graduate studies.

该奖项由材料研究部生物材料项目授予工程与应用科学学院的研究人员，他们与洛杉矶加州大学医学院的研究人员合作。该奖项由土木、机械制造创新部门的材料表面工程项目共同资助。本研究的主要目的是克服当前血管移植材料（如可膨胀聚四氟乙烯支架）遇到的经典生物学问题。该项目的科学目标是对薄膜镍钛诺（TFN）基材料的生物反应进行基本了解。 TFN包含仿生氧化钛（TiO）表面和智能设计的微孔图案。研究人员假设，与现有的移植材料相比，带负电荷的TiO表面更好地模拟了天然血管系统的电荷结构，从而减少血栓形成，同时促进再内皮化。通过智能设计的微孔进一步增强了这种仿生过程，这些微孔促进了在器械管腔侧形成的新生内膜与下方天然血管之间的直接细胞通讯，同时防止新生内膜增生。拟议的研究代表了一项跨学科合作，解决了当今覆膜支架和其他血管移植材料的重大局限性。该计划包括教育活动，以激发学生（从K-12到研究生水平）对科学和工程的兴趣。该奖项提供了一种潜在的新材料方法来治疗广泛的血管疾病，包括外周动脉疾病，影响超过1000万美国人。最近，使用可膨胀聚四氟乙烯覆膜支架治疗外周动脉疾病的情况有所增加，但1年内的失败率仍为35%，这表明这种类型的移植材料存在显著缺陷。三种主要失效机制是移植物血栓形成、边缘狭窄和缺乏再内皮化。为克服这些问题，本项目的研究将利用仿生学和智能设计的方法，开发一种新的血液相容性材料。该研究项目将为从K-12到研究生水平的广泛代表性不足的学生提供机会。鼓励K-12学生在当地学校每年两次的外联演讲中考虑科学和工程研究。该项目的研究人员将参与加州大学洛杉矶分校的卓越工程和多样性计划中心，以提供一个多样化的本科生群体（4-6），在一个季度内对该项目进行研究。此外，该项目将在协作环境中使用同伴指导过程，以教育本科生新的尖端技术，同时鼓励他们考虑研究生学习。