SBIR Phase I: Osteoconduction Determination of Mineral Coated Silicon Dioxide Nanosprings

SBIR 第一阶段：矿物涂层二氧化硅纳米弹簧的骨传导测定

• 批准号: 1315050
• 负责人: Jamie Hass
• 金额: $ 15万
• 依托单位: MJ3 Industries
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-07-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1315050&HistoricalAwards=false
• 关键词: SBIR; Phase; Osteoconduction; Determination; Mineral

This Small Business Innovation Research Phase 1 project addresses the failure of osseointegration, the lack of bonding between an orthopedic device and bone. Failure of the implant does occur with an unacceptably high rate (8-20%). The main driver for revision surgery is aseptic loosening of the implant, which occurs at a nanoscale. This can be very detrimental to the patient since the revised implants have higher complication rates. The research objective is to develop an orthopedic implant coating that mimics both the scaffolding and mineral structure of healing woven bone. Coated nanosprings, a synthetic collagen nanobiomaterial, mimics the scaffolding component of bone. This proposal is directed at developing a mineral layer on the nanosprings to make synthetic woven bone. Nanosprings can be grown on orthopedic devices. Metal alloy coated nanosprings are well tolerated by the body and increase the bone deposition rate, but the procedure is expensive. The mineral used for the proposed coating is inexpensive but lacks the scaffolding effects needed for bone integration. Combining these two synthetic biomaterials would provide the necessary economical scaffolding to facilitate osseointegration.The broader impact/commercial potential of this project to the osteoconductive biomaterial market is vast. The orthopedic market is a multi-billion dollar industry, which will increase as the baby boomer population ages. This technology can be employed in both animal and human devices, such as dental implants, prosthetics, and joint replacements. The potential commercialization options are partnering with an existing orthopedic device manufacturer for this add-on coating, or direct sales to the animal market, and then to the human market as the FDA allows. The coated nanosprings have the ability to greatly increase the rate and hardness of bone deposition. It is hypothesized that this increase around implants can have a significant clinical impact to improve the quality of patient?s lives as well as an economical benefit. This new technology can provide employment for scientists in both biologic and other hard science fields. The nanosprings are an ideal foundation for osteoconductive research. This synthetic collagen allows different coating material to be studied at a nanoscale level. Thus, providing both materials and biologic insight to the osseointegration process.

该小型企业创新研究第1阶段项目旨在解决骨整合失败，即骨科器械与骨骼之间缺乏粘合。植入物失效的发生率高得不可接受（8-20%）。翻修手术的主要驱动因素是植入物的无菌性松动，其发生在纳米级。这可能对患者非常不利，因为翻修植入物的并发症发生率更高。研究目的是开发一种骨科植入物涂层，模仿愈合编织骨的支架和矿物结构。涂层纳米弹簧，一种合成胶原纳米生物材料，模仿骨骼的支架成分。该提案旨在在纳米弹簧上开发矿物质层，以制造合成编织骨。纳米弹簧可以在矫形设备上生长。金属合金涂层纳米弹簧被身体很好地耐受，并增加骨沉积速率，但该过程是昂贵的。用于所提出的涂层的矿物质是廉价的，但缺乏骨整合所需的支架效应。结合这两种合成生物材料将提供必要的经济支架，以促进骨整合。该项目对骨传导生物材料市场的更广泛影响/商业潜力是巨大的。整形外科市场是一个价值数十亿美元的行业，随着婴儿潮一代人口的老龄化，这一行业将不断增长。该技术可用于动物和人类设备，如牙科植入物，假肢和关节置换。潜在的商业化选择是与现有的骨科器械制造商合作生产这种附加涂层，或者直接销售给动物市场，然后在FDA允许的情况下销售给人类市场。涂层纳米弹簧具有极大增加骨沉积速率和硬度的能力。据推测，植入物周围的这种增加可能会对改善患者质量产生重大临床影响？的生活，以及经济效益。这项新技术可以为生物和其他硬科学领域的科学家提供就业机会。 纳米弹簧是骨传导研究的理想基础。这种合成胶原蛋白允许在纳米级水平上研究不同的涂层材料。因此，为骨整合过程提供了材料和生物学见解。