Molecular Analysis of Lymphotoxin-ß-Receptor and Tumor Necrosis Factor Receptor p55 Mediated Hepatic Regeneration Processes (A06)

LTüR和TNFRp55的协同信号对肝脏再生是必不可少的。对肝细胞、内皮细胞或胆管细胞中LTβR特异缺陷的小鼠进行PHX后的详细分析，将发现这些细胞系中LTüR下游的信号通路是有效肝再生所必需的。最后，在之前的资助期间，通过转录组分析鉴定了几个LTüR/TNFRp55调节基因，其中包括小鼠球蛋白2，将分析它们调节肝脏再生的能力。

Cooperative signalling of LTßR and TNFRp55 is essential for liver regeneration. Detailed analysis post PHx in mice specifically deficient for LTβR in hepatocytes, endothelial cells or cholangiocytes will identify signalling pathways downstream of the LTßR in these cell lineages that are required for efficient liver regeneration. Finally, in the preceding funding periods several LTßR/TNFRp55 regulated genes, among them Murinoglobulin 2, were identified by transcriptome analysis which will be analyzed for their capacity to regulate liver regeneration.