Molecular mechanisms of two-component signal transduction in bacteria

细菌双组分信号转导的分子机制

• 批准号: DP0984536
• 负责人: Prof Jill Trewhella
• 金额: $ 29.1万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-06-02 至 2012-06-28
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0984536
• 关键词: Molecular; mechanisms; two; component; signal

The focus of this research is on the protein complexes that transmit signals in bacteria to elicit the desired responses to environmental stimuli. Like many dynamic processes in cells, signaling requires proteins that are flexible and hence resistant to high-resolution structural analysis using crystallography. We will make use of new research infrastructure at the Australian synchrotron and OPAL research reactor to overcome the challenges of flexibility in these systems. The proteins we will study are not found in humans, and hence our research will provide important structural data on potential targets for the design of novel antibiotics to fight bacterial infection.

这项研究的重点是细菌中传递信号以引起对环境刺激所需反应的蛋白质复合体。就像细胞中的许多动态过程一样，信号传递需要灵活的蛋白质，因此不能使用结晶学进行高分辨率的结构分析。我们将利用澳大利亚同步加速器和Opal研究反应堆的新研究基础设施来克服这些系统灵活性方面的挑战。我们将研究的蛋白质在人类中没有发现，因此我们的研究将为设计新的抗生素以对抗细菌感染的潜在靶点提供重要的结构数据。