Molecular Mechanisms of Biochemical Regulation: Neutron and X-ray Scattering Studies

生化调节的分子机制：中子和 X 射线散射研究

• 批准号: FF0457488
• 负责人: Prof Jill Trewhella
• 金额: $ 74.32万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Federation Fellowships
• 财政年份: 2005
• 资助国家: 澳大利亚
• 起止时间: 2005-07-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FF0457488
• 关键词: Molecular; Mechanisms; Biochemical; Regulation; Neutron

This project will develop and use novel neutron and x-ray scattering methods to study the molecular mechanisms by which nature regulates biochemical processes. Healthy function requires cells to tightly control and coordinate a myriad of molecular activities. My research focuses on a set of interdependent molecular networks inside cells whose behavior is controlled by the so-called 'second messengers' that translate external signals into the right cellular responses. The proposed experiments will provide a unique structural framework by which we can understand how these signals are transmitted. Such knowledge is an important foundation for advances in biomedical research and biotechnology applications.

该项目将开发和使用新的中子和X射线散射方法来研究自然调节生物化学过程的分子机制。 健康的功能需要细胞严格控制和协调无数的分子活动。 我的研究重点是细胞内一组相互依赖的分子网络，其行为由所谓的“第二信使”控制，将外部信号转化为正确的细胞反应。 拟议的实验将提供一个独特的结构框架，通过它我们可以了解这些信号是如何传输的。 这些知识是生物医学研究和生物技术应用取得进展的重要基础。