RCN: Integrating and Coordinating a National and International Plant, Algae, and Microbial Metabolomics Research Coordination Network

美国参与者：Lloyd W.萨姆纳（塞缪尔·罗伯茨诺布尔基金会）、奥利弗·菲恩（加州大学戴维斯分校）、詹姆斯·廖（加州大学洛杉矶）、乔治·詹德（博伊斯汤普森研究所）、巴兹尔·尼古劳（爱荷华州州立大学）、理查德·A.狄克逊（北德克萨斯大学），让S。VanderGheynst（加州大学戴维斯分校）（加州大学戴维斯分校）（加州大学戴维斯分校）（加州大学戴维斯分校）（USDA-ARS，Gainsville）和Eric Schmelz（美国农业部-农业研究所，Gainsville）日本参与者：齐藤和树（理研植物科学中心），Masanori Arita（东京大学），Eiichiro Eiusaki（大坂大学），Yutaka Okumoto（京都大学），筱崎一夫（理研植物科学中心），Jun菊池（理研植物科学中心）山崎真美（千叶大学），铃木秀之（Kazusa DNA研究所），太田大作（大坂府立大学）、Shigehiko Kanaya（NAIST）、Hiroshi Shimizu（大坂大学），Fumio Matsuda（大坂大学），Naoki Mori（京都大学），吉永直子（京都大学），和Yutaka Okumoto（京都大学）该项目的主要目标是开发一种植物，藻类和微生物代谢组学研究协调网络（PAMM NET）将促进有效沟通，增加合作机会，建立社区共识，确定代谢组学的关键挑战，并促进协调社区的经验努力，以应对这些挑战。 PAMM NET的参与将向公众开放，并将开始通过联合NSF-JST代谢组学低碳社会计划资助的四个独立和国际项目的统一。 这种统一将进一步扩大NSF目前在植物，藻类和微生物代谢组学方面的投资，并将通过定期视频会议和年度面对面的计划会议和研讨会来实现。 该团队将作为一个核心，建立一个更加统一的国家和国际PAMM网络，该网络将确定和寻求解决方案，以应对仍然阻碍代谢组学充分发挥潜力的关键挑战。 为此，将征聘一名网络协调员，作为本组织的专职倡导者，促进一体化，并为网络成果的协商一致报告提供后勤支持。 最初的核心和网络协调员将招募来自美国和全球植物，藻类和微生物代谢组学社区的公众参与者，以建立工作焦点小组。 这些焦点小组将积极讨论与代谢组学相关的当前重大挑战以及这些挑战的潜在解决方案。 PAMM NET认识到，许多挑战将需要更大的生物学，技术和生物信息学社区的参与，因此PAMM NET将从这些不同的群体中招募反馈和积极参与，以最好地制定应对重大挑战的经验解决方案。 PAMM NET将进一步促进代谢组学协会美国国家分会的发展，以更好地服务于美国代谢组学社区的需求并提供长期解决方案。 PAMM NET将与其他联邦资助的项目（如NIH支持的国家代谢组学中心）建立一个应答机制，以更好地协调联邦资助部门和科学学科的工作。 最后，PAMM NET将启动与全球代谢组学社区的对话，以确定和寻求合作的国际代谢组学资助机会。 协调一致的社区努力有望更加热情、高效和富有成效，从而导致新的和有利的科学发现和创新。 PAMM NET RCN认为，以研究为基础的教育和培训是培养年轻科学家从事富有成果的职业的一个组成部分。 因此，PAMM NET将鼓励，协调和支持早期职业科学家（年轻教师，研究生，博士后和数量有限的本科生）参加与每个NSF-JST代谢组学计划项目相关的年度研讨会。 这些方案性讲习班将包括代谢组学研究不同方面的实际演示，从使用复杂的色谱、质谱和基于NMR的代谢物分析工具，到代谢组学数据的计算和统计分析和解释。此外，该区域网络将组织和支持与国际植物生物学或代谢组学会议有关的年度研讨会（例如，代谢组学学会年会或美国植物生物学家学会年会）。有关PAMM NET活动的信息将存放在项目网站（待开发）上，产生的资源将转移到代谢组学学会网站，以供长期维护和支持。

US Participants: Lloyd W. Sumner (Samuel Roberts Noble Foundation); Oliver Fiehn (University of California, Davis), James Liao (University of California, Los Angeles), Georg Jander (Boyce Thompson Institute), Basil Nikolau (Iowa State University), Richard A. Dixon (University of North Texas), Jean S. VanderGheynst (University of California, Davis), John Labavitch (University of California, Davis), Tobias Kind (University of California, Davis), William Wikoff (University of California, Davis), Alisa Huffaker (USDA-ARS, Gainsville), and Eric Schmelz (USDA-ARS, Gainsville)Japan Participants: Kazuki Saito (Riken Plant Science Center), Masanori Arita (University of Tokyo), Eiichiro Fukusaki (Osaka University), Yutaka Okumoto (Kyoto University), Kazuo Shinozaki (Riken Plant Science Center), Jun Kikuchi (Riken Plant Science Center), Mami Yamazaki (Chiba University), Hideyuki Suzuki (Kazusa DNA Research Institute), Daisaku Ohta (Osaka Prefecture University), Shigehiko Kanaya (NAIST), Hiroshi Shimizu (Osaka University), Fumio Matsuda (Osaka University), Naoki Mori (Kyoto University), Naoko Yoshinaga (Kyoto University), and Yutaka Okumoto (Kyoto University)The primary goal of this project is to develop a Plant, Algae and Microbial Metabolomics Research Coordination Network (PAMM NET) that will promote effective communication, enhance opportunities for collaboration, build community consensus, identify key challenges in metabolomics, and facilitate coordinated community empirical efforts to meet these challenges. Participation in PAMM NET will be open to the public, and will begin with the unification of four independent and international projects funded through the joint NSF-JST Metabolomics for a Low Carbon Society program. This unification will further amplify NSF's current investment in plant, algae and microbial metabolomics, and will be achieved through regular videoconferences and annual face-to-face program meetings and workshops. This team will serve as a nucleus to build forth a more unified national and international PAMM NET that will identify and pursue solutions to the key challenges that still impede the full potential of metabolomics. This will be facilitated through the recruitment of a network coordinator who will serve as a dedicated advocate for the organization, facilitate integration, and provide logistical support for consensus reporting of the network outcomes. The initial nucleus and the network coordinator will then recruit public participants from the US and global plant, algae, and microbial metabolomics communities to build working focus groups. These focus groups will actively discuss the current grand challenges associated with metabolomics and potential solutions to these challenges. The PAMM NET recognizes that many challenges will need the involvement of the larger biology, technology, and bioinformatics communities and PAMM NET will therefore recruit feedback and active participation from these diverse groups to best formulate empirical solutions to the grand challenges. PAMM NET will further contribute to the development of a US National Chapter of the Metabolomics Society to better serve and provide long-term solutions for the needs of the US metabolomics community. PAMM NET will build a repartee with other federally funded programs such as the NIH-supported National Metabolomics Centers to better coordinate efforts across federal funding divisions and scientific disciplines. Finally, PAMM NET will initiate conversations with the global metabolomics community to identify and pursue cooperative international metabolomics funding opportunities. A coordinated community effort is expected to be more cordial, efficient, and productive, thereby leading to new and enabling scientific discoveries and innovations. The PAMM NET RCN considers research-based education and training as an integral part of preparing young scientists for fruitful careers. Accordingly, the PAMM NET will encourage, coordinate and support the attendance of early-career scientists (young faculty, graduate students, post-docs and a limited number of undergraduate students) at annual workshops that are associated with each of the NSF-JST Metabolomics programmatic projects through a limited number of scholarships. These programmatic workshops will include hands-on demonstrations of different aspects of metabolomics research that will range from the use of sophisticated chromatographic, mass-spectrometric and NMR-based tools for metabolite analysis, to computational and statistical analyses and interpretation of metabolomics data. In addition, this RCN will organize and support an annual workshop associated with international plant biology or metabolomics meetings (e.g., Annual Meeting of the Metabolomics Society or the Annual Meeting of the American Society of Plant Biologists). Information about the activities of the PAMM NET will be housed at the project website (to be developed) and the resources generated will be transferred to the Metabolomics Society website for long-term maintenance and support.