SBIR Phase I: Cognitive testing based on visual paradigms

这个小企业创新研究（SBIR）第一阶段项目将建立将认知功能障碍的新颖视觉测试转化为临床实践的可行性。强烈需要既足够有效又足够高效的测试，以用作筛选/监测工具。拟议的视觉测试旨在通过独特地结合心理测量学神经科学的先进技术来满足这一需求。第一阶段的计划是进行真实的和模拟的病例对照研究，以量化测试有效性和效率之间的权衡。该项目的更广泛的影响/商业潜力是显著改善认知功能障碍患者的预后，同时降低医疗成本。认知功能障碍是常见行为障碍的标志，导致大量的人类痛苦和社会成本。拟议的技术平台将能够安全，有效和高效地测试认知功能障碍。其他应用包括临床和健康人群的认知训练，如运动员，司机和行李检查员。拟议中的测试还可以帮助阐明大脑异常、认知功能障碍和行为中断之间的因果关系。

This Small Business Innovation Research (SBIR) Phase I project will establish the feasibility of translating novel visual tests of cognitive dysfunction to clinical practice. There is a strong need for tests that are both effective enough and efficient enough to be used as screening/monitoring tools. The proposed visual tests are designed to meet this need by uniquely combining advanced techniques from psychometrics & neuroscience. The Phase I plan is to perform real and simulated case-control studies in order to quantify the tradeoff between test effectiveness and efficiency. The proposed innovation is expected to substantially improve test efficiency with no loss or even gain in effectiveness.The broader impact/commercial potential of this project is to significantly improve outcomes for individuals with cognitive dysfunction while reducing healthcare costs. Cognitive dysfunction is a hallmark of common behavioral disorders, leading to substantial human suffering and societal costs. The proposed technology platform will enable safe, effective and efficient testing of cognitive dysfunction. Other applications include cognitive training for both clinical and healthy populations, such as athletes, drivers, and baggage screeners. The proposed tests could also help elucidate the causal links between brain abnormalities, cognitive dysfunction, and behavioral disruptions.