SBIR Phase I: Cognitive testing based on visual paradigms

这个小型企业创新研究(SBIR)第一阶段项目将确立将认知功能障碍的新视觉测试转化为临床实践的可行性。迫切需要既足够有效又足够有效的测试，以用作筛查/监测工具。拟议的视觉测试正是为了满足这一需求而设计的，它独特地结合了心理测量学和神经科学的先进技术。第一阶段的计划是进行真实和模拟的病例对照研究，以量化测试有效性和效率之间的权衡。预计拟议的创新将在不损失甚至不增加有效性的情况下大幅提高测试效率。该项目的更广泛影响/商业潜力是显著改善认知功能障碍患者的结果，同时降低医疗成本。认知功能障碍是常见行为障碍的一个特征，会导致严重的人类痛苦和社会代价。拟议的技术平台将使认知功能障碍的测试变得安全、有效和高效。其他应用包括为临床和健康人群提供认知培训，如运动员、司机和行李安检员。拟议的测试还可以帮助阐明大脑异常、认知功能障碍和行为障碍之间的因果联系。

This Small Business Innovation Research (SBIR) Phase I project will establish the feasibility of translating novel visual tests of cognitive dysfunction to clinical practice. There is a strong need for tests that are both effective enough and efficient enough to be used as screening/monitoring tools. The proposed visual tests are designed to meet this need by uniquely combining advanced techniques from psychometrics & neuroscience. The Phase I plan is to perform real and simulated case-control studies in order to quantify the tradeoff between test effectiveness and efficiency. The proposed innovation is expected to substantially improve test efficiency with no loss or even gain in effectiveness.The broader impact/commercial potential of this project is to significantly improve outcomes for individuals with cognitive dysfunction while reducing healthcare costs. Cognitive dysfunction is a hallmark of common behavioral disorders, leading to substantial human suffering and societal costs. The proposed technology platform will enable safe, effective and efficient testing of cognitive dysfunction. Other applications include cognitive training for both clinical and healthy populations, such as athletes, drivers, and baggage screeners. The proposed tests could also help elucidate the causal links between brain abnormalities, cognitive dysfunction, and behavioral disruptions.