Industrialization of Biology: A Roadmap to Accelerate Advanced Manufacturing of Chemicals, 500 5th Street, N.W., Washington, DC

1344363 Friedman，Douglas美国国家科学院国家研究理事会将通过其化学科学与技术委员会和生命科学委员会，以化学品制造为案例研究，确定通过生物系统实现先进制造潜力所需的知识、工具、技术和系统方面的关键差距。一个特设委员会将制定一个路线图，说明实现利用生物系统先进制造化学品所需的基础科学和工程能力的必要进展。在合成化学，代谢工程，分子生物学和合成生物学的接口工作，该委员会将确定下一代化学制造的关键技术目标，确定必须填补的知识差距，以实现这些目标，以及实现这些目标的目标和时间表。它还将考虑实现路线图目标所需的技能，以及培养所需的熟练科学家和工程师骨干所需的培训机会。虽然专注于化学品的工业制造，但预计路线图挑战将推动健康，能源和环境应用新发展所需的工具和技术。

1344363Friedman, DouglasThe National Research Council of the National Academy of Sciences, through its Board on Chemical Sciences and Technology and its Board on Life Sciences, will identify key gaps in knowledge, tools, techniques and systems needed to realize the potential for advanced manufacturing via biological systems, using manufacturing of chemicals as the case study. An ad hoc committee will develop a roadmap of necessary advances in basic science and engineering capabilities needed to realize advanced manufacturing of chemicals using biological systems. Working at the interface of synthetic chemistry, metabolic engineering, molecular biology, and synthetic biology, the committee will identify key technical goals for this next-generation chemical manufacturing, identify the knowledge gaps which must be filled to meet those goals, and targets and timelines for achieving them. It will also consider the skills necessary to accomplish the roadmap goals, and what training opportunities are required to produce the cadre of skilled scientists and engineers needed. While focused on industrial manufacturing of chemicals, it is anticipated that the roadmap challenges will advance tools and techniques that are also required for new developments in health, energy, and environmental applications.