CAREER: A self-powered biosensing microsystem

我们将制造并表征一种自供电的生物传感微系统，同时产生生物电并监测血糖。这将通过使用惯性功率清除设计来实现，通过酶和三维纳米线阵列的耦合将间质葡萄糖转化为能量，从而潜在地为超低功率植入式血糖监测器供电。智力价值：对糖尿病患者进行持续的、自给自足的血糖监测是相当重要的，可以挽救生命。建议的自供电生物传感微系统将监测血糖水平，它体现了两个关键的新贡献：(1)该方法消除了对恒电位器电路和外部电源或电池的需要，从而显著提高了速度和能源效率。基于三维纳米线阳极与能量采集电路和电容器融合的酶生物燃料电池将提供集成设备，这些设备将检测输入电位并增加电力以运行发光二极管。(2)这项工作既是创新的，也是变革性的，因为它将提供一个自主的、自我供电的、低功率的生物传感微系统。生物传感微系统将实时产生驱动信号，并仅通过在电容器中产生和积累由于葡萄糖氧化的催化而产生的电能来周期性地为电子设备供电。广泛影响：研究和教育目标都具有重要的更广泛的影响。研究解决了糖尿病治疗中的一个关键问题--一种用于持续监测血糖的自供电生物传感微系统。这两个领域的结合：纳米线、基于酶的生物燃料电池和生物传感系统，可以开启自供电生物传感器微系统用于血糖监测的新纪元。展示一种自给自足、稳定、连续、长期的葡萄糖生物传感微系统可能会改善糖尿病患者的生活质量。教育部分丰富和补充了密歇根州立大学旨在增加少数族裔和女性参与数学和科学的其他项目。这些学生接触到现实世界的问题及其解决方案，将使他们更好地欣赏科学研究的贡献。

We will fabricate and characterize a self-powered biosensing microsystem that simultaneously generates bioelectricity and monitors glucose. This will be accomplished by using inertial power scavenging design by converting interstitial glucose into energy through the coupling of enzymes and three-dimensional nanowire arrays to potentially power ultra-low power implantable glucose monitors. Intellectual Merit: Continuous, self-powered monitoring of glucose in diabetics is quite important and will save lives. The proposed self-powered biosensing microsystem will monitor sugar levels and it embodies two key new contributions: (1) The approach eliminates the need for a potentiostat circuit and an external power source or batteries, thus leading to dramatic improvements in both speed and energy efficiency. Enzyme biofuel cells based on three-dimensional nanowire anodes fused with an energy harvesting circuit and a capacitor will provide integrated devices that will sense input potential and step up the electric power to operate a light emitting diode. (2) The work is both innovative and transformational, since it will provide an autonomous, self-powered, low-power biosensing microsystem. The biosensing microsystem will generate a drive signal in real-time and periodically power an electrical device solely by generating and accumulating electrical power in the capacitor as a result of the catalysis of glucose oxidation.Broad Impact: Both the research and educational objectives have a significant broader impact.The research addresses a crucial problem in diabetes treatment - a self-powered biosensing microsystem for continuous monitoring of blood glucose. The combination of the two areas; nanowire enzyme-based biofuel cell and biosensing system; can usher in a new era in self-powered biosensor microsystems for glucose monitoring. Demonstration of a self-powered, stable, continuous, long-term biosensing microsystem for glucose could lead to improvement in the quality of life for people with diabetes. The educational component enriches and complements other programs at UMBC that are designed to increase minority and female participation in math and science. The exposure of these students to a real-world problem and its solution will enable them to better appreciate the contribution of scientific research.