Collaborative: A mobile smart glucose monitoring system

协作：移动智能血糖监测系统

• 批准号: 1802948
• 负责人: Gymama Slaughter
• 金额: $ 33万
• 依托单位: University of Maryland Baltimore County
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-01 至 2019-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1802948&HistoricalAwards=false
• 关键词: Collaborative; mobile; smart; glucose; monitoring

The objective of this research proposal is to develop a class of novel mobile smart glucose monitoring system (mSGMS) that is able to detect glucose levels from interstitial fluid without the use of an external power source or a battery. In a clinical context, the work will provide a new technique for continuous glucose measurement that is far more effective at detecting transient changes in glucose levels. The mSGMS will provide faster analysis and better diagnostic information, with the added benefit of responding rapidly to abnormalities in glucose levels. The ability to continuously monitor glucose means it will no longer be necessary to frequently sample blood with some associated degree of inconvenience and pain. The smart glucose monitoring system integrated with data transmission-communication modules could potentially replace continuous glucose monitors (CGMs) used in monitoring blood glucose in healthcare applications. Educational outreach activities and research experiences will be developed to engage Baltimore area high school students, undergraduates, and graduate students in the proposed research. This work will be of significant use in improving glycemic control and improving the quality of life with fewer complications and lower healthcare costs. A class of novel stretchable and flexible mobile smart glucose monitoring system (mSGMS) capable of continuous glucose measurement that is far more effective at detecting transient changes in glucose levels from interstitial fluid is proposed. The development of the mSGMS will be achieved through the following specific aims: (Aim 1) Design, fabricate and test the smart glucose monitoring system capable of detecting glucose levels. (Aim 2) Develop a mobile smart glucose monitoring system (mSGMS) that integrates wireless telemetry and performs data collection, signal processing, data analysis, and information transmission to patient and caregivers, and (Aim 3) encapsulate the smart glucose monitoring system. The proposed research is innovative because the mSGMS generates and accumulates electrical power in a capacitor via a charge pump integrated circuit (IC) as a result of the oxidation of interstitial glucose for sensing glucose without the use of a potentiostat circuit or an external power source, while simultaneously via a DC-DC converter powering the data acquisition, processing, and data transmission-communication modules. This research offers tremendous opportunities to overcome the limitations of commercially available glucose monitoring technologies by providing a device that allows sensitive and rapid detection of transient changes in interstitial glucose concentration. The proposed studies will generate continuous glucose recording in interstitial fluid samples from patients with type 1 diabetes for long duration.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

本研究方案的目的是开发一种新型的移动智能血糖监测系统(MSGMS)，该系统能够在不使用外部电源或电池的情况下检测组织间液中的血糖水平。在临床上，这项工作将提供一种新的连续血糖测量技术，在检测血糖水平的瞬时变化方面要有效得多。MSGMS将提供更快的分析和更好的诊断信息，并增加了对血糖水平异常做出快速反应的好处。持续监测血糖的能力意味着不再需要频繁采集血液样本，从而带来一定程度的不便和疼痛。集成了数据传输通信模块的智能血糖监测系统可能会取代医疗保健应用中用于监测血糖的连续血糖监测仪(CGM)。将开展教育推广活动和研究经验，以吸引巴尔的摩地区的高中生、本科生和研究生参与拟议的研究。这项工作将在改善血糖控制和以更少的并发症和更低的医疗成本提高生活质量方面发挥重要作用。提出了一种新型的可伸缩、灵活的移动智能血糖监测系统(MSGMS)，该系统能够连续测量血糖，更有效地检测间质液中血糖的瞬时变化。MSGMS的开发将通过以下具体目标来实现：(目标1)设计、制造和测试能够检测血糖水平的智能血糖监测系统。(目标2)开发一种集无线遥测、数据采集、信号处理、数据分析和信息传输于一体的移动智能血糖监测系统(MSGMS)，并将其封装为智能血糖监测系统。这项拟议的研究具有创新性，因为mSGMS通过电荷泵集成电路(IC)产生和积累电容器中的电能，作为间隙葡萄糖氧化的结果，无需使用恒电位电路或外部电源，同时通过DC-DC转换器为数据采集、处理和数据传输-通信模块供电。这项研究提供了一种设备，可以灵敏、快速地检测间质葡萄糖浓度的瞬时变化，从而为克服商业化血糖监测技术的局限性提供了巨大的机会。这项拟议的研究将在1型糖尿病患者的间质液体样本中产生长期的连续血糖记录。这一奖项反映了NSF的法定使命，并已通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。