CAREER: Myco-fluidics -- Mathematics at the interface of fluid dynamics and fungal biology

职业：真菌流体学——流体动力学和真菌生物学交叉领域的数学

• 批准号: 1351860
• 负责人: Marcus Roper
• 金额: $ 42.5万
• 依托单位: University of California-Los Angeles
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-07-01 至 2021-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1351860&HistoricalAwards=false
• 关键词: CAREER; Myco; fluidics; Mathematics; interface

This project combines mathematical modeling and physical experiments to study the dispersal and growth of fungi and to predict how fungi will respond to our changing Earth. The mathematical work in this project includes probability theory, optimization, dynamical systems, fluid mechanics, and the synthesis of new models. The central biological questions addressed are: (i) How do adaptive fungal networks form and how are they optimized for mixing and transport? (ii) How does the flow in these networks self-organize to eliminate congestion? (iii) What adaptations are used by fungi to control their spore dispersal? This project will develop interdisciplinary teaching and research methods connecting physics, genetics and the environment. Teaching and research are integrated through the interdisciplinary training of graduate and undergraduate students in mathematics and biology. New undergraduate mathematical modeling seminars and classes that emphasize societal impacts will be developed. Undergraduate researchers will be mentored to make key research contributions.Humans, mammals, fish, reptiles and plants represent only a razor's edge of the Earth's immense biodiversity. Most of the Earth's multicellular species are undescribed and lie inside of plants or buried in the soil and undergrowth. Millions of these undescribed species are thought to be fungi. Increasing our knowledge of these species is important because emerging fungal diseases pose a danger to society by threatening our forests, crops and wildlife. This project will provide mechanistic models of adaptation in fungal networks and the physical processes involved in fungal dispersal. These models will provide a platform for predicting which fungi are capable of adapting and dispersing into new habitats and the rate at which they will do so. The discovered strategies used by fungal transport networks can be applied to scheduling problems in a variety of other settings such as traffic or data networks.

该项目结合数学建模和物理实验来研究真菌的扩散和生长，并预测真菌将如何应对我们不断变化的地球。 在这个项目中的数学工作包括概率论，优化，动力系统，流体力学和新模型的合成。解决的中心生物学问题是：（i）适应性真菌网络如何形成，以及它们如何优化混合和运输？(ii)这些网络中的流量如何自组织以消除拥塞？ (iii)真菌利用什么样的适应性来控制孢子的传播？该项目将开发连接物理学、遗传学和环境的跨学科教学和研究方法。教学和研究通过研究生和本科生在数学和生物学的跨学科培训相结合。将开发新的本科数学建模研讨会和课程，强调社会影响。本科生研究人员将得到指导，以作出关键的研究贡献。人类，哺乳动物，鱼类，爬行动物和植物只代表剃刀的边缘，地球上的巨大的生物多样性。地球上大多数的多细胞物种都没有被描述过，它们躺在植物体内或埋在土壤和灌木丛中。 数以百万计的这些未描述的物种被认为是真菌。增加我们对这些物种的了解很重要，因为新出现的真菌疾病通过威胁我们的森林，作物和野生动物对社会构成危险。该项目将提供真菌网络中的适应机制模型和真菌传播中涉及的物理过程。这些模型将提供一个平台，用于预测哪些真菌能够适应和分散到新的栖息地，以及它们这样做的速度。 真菌运输网络所使用的发现策略可以应用于各种其他环境中的调度问题，如交通或数据网络。

项目成果

Fast asymptotic-numerical method for coarse mesh particle simulation in channels of arbitrary cross section

任意截面通道中粗网格粒子模拟的快速渐近数值方法

• DOI: 10.1016/j.jcp.2022.111622
• 发表时间: 2022
• 期刊: Journal of Computational Physics
• 影响因子: 4.1
• 作者: Christensen, Samuel;Chu, Raymond;Anderson, Christopher;Roper, Marcus
• 通讯作者: Roper, Marcus