CAREER: Metal-Catalyzed Alkene Hydroacylation: Establishing a New Platform for the Synthesis and Functionalization of Heterocycles

在这项由化学系化学合成计划资助的项目中，爱荷华州立大学的李维·M·斯坦利教授正在开发杂环化合物合成和功能化的新催化方法。这项研究涉及金属催化的烯烃氢酰化反应和烯烃上的醛加成反应，以使氮杂环的合成和官能化成为可能。这项研究计划包括识别和开发控制烯烃氢酰化反应的区域选择性和对映体选择性的过渡金属催化剂。该奖项支持由Stanley教授领导的教育计划，以扩大高级化学学生的化学学习社区，以提高爱荷华州立大学化学学生的保留、成绩和参与度，并通过一个实验有机化学实验室实施具有实际应用价值的真实研究经验。该项目专注于建立烯烃氢酰化反应作为合成和进一步功能化的平台，类具有医学意义的氮杂环。这项工作的更广泛影响包括发现具有新的和/或改进的性质的杂环化合物的潜在社会效益，以及确定导致更稳定和更有选择性的催化剂结构的催化剂设计原则。该项目为本科生和研究生提供了在现代合成有机和有机金属化学研究方面获得经验的机会，同时通过扩大爱荷华州立大学的化学学习社区来提高保留率、成就和参与度。

In this project, funded by the Chemical Synthesis program of the Chemistry Division, Professor Levi M. Stanley of Iowa State University is developing new catalytic methods for the synthesis and functionalization of heterocyclic compounds. The research involves the development of metal-catalyzed alkene hydroacylation reactions and additions of aldehydes across alkenes, to enable the synthesis and functionalization of nitrogen heterocycles. This research program encompasses the identification and development of transition-metal catalysts that control regioselectivity and enantioselectivity of the alkene hydroacylation reactions. This award is supporting educational programs led by Professor Stanley to expand the Chemistry Learning Community for upper-level chemistry students to improve retention, achievement, and engagement among chemistry students at Iowa State University and the implementation of an authentic research experience with practical applications through an experimental organic chemistry laboratory.This project focuses on the establishment of alkene hydroacylation reactions as a platform to synthesize, and further functionalize, classes of medicinally important nitrogen heterocycles. The broader impacts of this work include potential societal benefits from the discovery of heterocyclic compounds with new and/or improved properties and the identification of catalyst design principles leading to more stable and selective catalyst structures. The project provides opportunities for undergraduate and graduate students to gain experience in modern synthetic organic and organometallic chemistry research while improving retention, achievement, and engagement through expansion of the Chemistry Learning Community at Iowa State University.