CAREER: Metal-Catalyzed Alkene Hydroacylation: Establishing a New Platform for the Synthesis and Functionalization of Heterocycles

在这个由化学部化学合成项目资助的项目中，爱荷华州立大学的Levi M. Stanley教授正在开发新的催化方法来合成和功能化杂环化合物。该研究涉及金属催化烯烃氢酰化反应的发展和烯烃上醛的添加，以实现氮杂环的合成和功能化。本研究项目包括识别和开发过渡金属催化剂，控制烯烃氢酰化反应的区域选择性和对映选择性。该奖项支持由Stanley教授领导的教育项目，旨在扩大化学学习社区，为爱荷华州立大学的高级化学学生提供学习机会，提高他们的记忆力、成绩和参与度，并通过实验有机化学实验室将真实的研究经验与实际应用结合起来。本项目重点建立烯烃加氢酰化反应，作为合成并进一步功能化具有重要药用意义的氮杂环类化合物的平台。这项工作的更广泛的影响包括潜在的社会效益，包括发现具有新的和/或改进性质的杂环化合物，以及确定导致更稳定和选择性催化剂结构的催化剂设计原则。该项目为本科生和研究生提供了获得现代合成有机和有机金属化学研究经验的机会，同时通过扩大爱荷华州立大学的化学学习社区，提高学生的保留率、成就和参与度。

In this project, funded by the Chemical Synthesis program of the Chemistry Division, Professor Levi M. Stanley of Iowa State University is developing new catalytic methods for the synthesis and functionalization of heterocyclic compounds. The research involves the development of metal-catalyzed alkene hydroacylation reactions and additions of aldehydes across alkenes, to enable the synthesis and functionalization of nitrogen heterocycles. This research program encompasses the identification and development of transition-metal catalysts that control regioselectivity and enantioselectivity of the alkene hydroacylation reactions. This award is supporting educational programs led by Professor Stanley to expand the Chemistry Learning Community for upper-level chemistry students to improve retention, achievement, and engagement among chemistry students at Iowa State University and the implementation of an authentic research experience with practical applications through an experimental organic chemistry laboratory.This project focuses on the establishment of alkene hydroacylation reactions as a platform to synthesize, and further functionalize, classes of medicinally important nitrogen heterocycles. The broader impacts of this work include potential societal benefits from the discovery of heterocyclic compounds with new and/or improved properties and the identification of catalyst design principles leading to more stable and selective catalyst structures. The project provides opportunities for undergraduate and graduate students to gain experience in modern synthetic organic and organometallic chemistry research while improving retention, achievement, and engagement through expansion of the Chemistry Learning Community at Iowa State University.