CAREER: Metal-Catalyzed Alkene Hydroacylation: Establishing a New Platform for the Synthesis and Functionalization of Heterocycles

在这个由化学系化学合成项目资助的项目中，Levi M.爱荷华州州立大学的斯坦利正在开发新的催化方法来合成和功能化杂环化合物。 该研究涉及金属催化的烯烃加氢酰化反应和醛在烯烃上的加成反应的发展，以实现氮杂环的合成和官能化。 该研究计划包括识别和开发控制烯烃加氢酰化反应的区域选择性和对映选择性的过渡金属催化剂。 该奖项是支持由斯坦利教授领导的教育计划，以扩大化学学习社区的上层化学学生，以提高保留，成就，和参与化学学生在爱荷华州州立大学和实施一个真实的研究经验与实际应用，通过实验有机化学实验室。该项目的重点是建立烯烃加氢酰化反应作为一个平台，合成并进一步官能化医药上重要氮杂环类。 这项工作的更广泛的影响包括发现具有新的和/或改进的性质的杂环化合物以及确定导致更稳定和选择性的催化剂结构的催化剂设计原则的潜在社会效益。 该项目为本科生和研究生提供了机会，以获得现代合成有机和有机金属化学研究的经验，同时提高保留，成就和参与通过化学学习社区在爱荷华州州立大学的扩展。

In this project, funded by the Chemical Synthesis program of the Chemistry Division, Professor Levi M. Stanley of Iowa State University is developing new catalytic methods for the synthesis and functionalization of heterocyclic compounds. The research involves the development of metal-catalyzed alkene hydroacylation reactions and additions of aldehydes across alkenes, to enable the synthesis and functionalization of nitrogen heterocycles. This research program encompasses the identification and development of transition-metal catalysts that control regioselectivity and enantioselectivity of the alkene hydroacylation reactions. This award is supporting educational programs led by Professor Stanley to expand the Chemistry Learning Community for upper-level chemistry students to improve retention, achievement, and engagement among chemistry students at Iowa State University and the implementation of an authentic research experience with practical applications through an experimental organic chemistry laboratory.This project focuses on the establishment of alkene hydroacylation reactions as a platform to synthesize, and further functionalize, classes of medicinally important nitrogen heterocycles. The broader impacts of this work include potential societal benefits from the discovery of heterocyclic compounds with new and/or improved properties and the identification of catalyst design principles leading to more stable and selective catalyst structures. The project provides opportunities for undergraduate and graduate students to gain experience in modern synthetic organic and organometallic chemistry research while improving retention, achievement, and engagement through expansion of the Chemistry Learning Community at Iowa State University.