Neural Mechanisms Regulating Reward Responses

大脑是如何决定什么时候该工作去获取食物，什么时候该努力寻找配偶的呢？根据动物的内部状态，大脑会发生什么变化来分配特定奖励的优先级？在这些实验中，研究人员将研究激素雌二醇如何在雌性大鼠的大脑中起作用，以减少食物摄入和食物动机，同时增强生殖动机。研究人员将研究大脑的化学反应，因为它对先前与奖励配对的提示做出反应。这些研究将调查神经递质多巴胺的变化如何受到不同荷尔蒙状态下与奖励相关的线索的影响。这些结果将增强对激素影响动机和决策过程的作用的理解，并将有助于对神经可塑性的理解。在雌性大鼠中，雌二醇减少食物摄入和食物的动机，同时增强雌性生殖动机。此外，多巴胺（DA）增加在脑桥核（NAc）的提示，已预先配对的奖励，和NAc DA是牵连的奖励的激励显着性归因。DA信号是如何影响奖励相关的线索在不同的激素状态下，通过雌二醇影响这些线索的激励显着性的机制，是至关重要的，我们在雌性大鼠的动机的理解。 实验将使用快速扫描循环伏安法来测量在不同激素条件下对配偶或食物做出反应期间NAc的核心和外壳中的自发DA释放，使用我们的新范式来量化女性生殖动机。DA在调节雌性从选择食物到选择配偶的转换中的作用将被确定。研究生和本科生将参与这些研究。调查结果将通过科学出版物以及在地方和国家一级的会议上的介绍进行传播。学生在实验室的具体活动包括实验室技能的前/后评估和BrainsRule的开发！向当地和底特律的中学生介绍动机和选择的神经机制。

How does the brain decide when it is time to work to obtain food or put its effort into finding a mate? What changes in the brain to assign priorities to specific rewards depending on the internal state of the animal? In these experiments, the investigators will study how the hormone, estradiol, acts in the brain of the female rat to decrease food intake and the motivation for food, while enhancing reproductive motivation. The investigators will study the chemistry of the brain as it responds to the presentation of a cue that has been previously paired with a reward. These studies will investigate how changes in the neurotransmitter, dopamine, is affected by reward-related cues under different hormonal states. These results will enhance the understanding of the role of hormones to influence motivation and decision making processes, and will contribute to the understanding of neuroplasticity in general. In the female rat, estradiol decreases food intake and the motivation for food while enhancing female reproductive motivation. Further, dopamine (DA) increases in the nucleus accumbens (NAc) upon the presentation of a cue that has been previously paired with a reward, and NAc DA is implicated in attribution of incentive salience for that reward. How DA signaling is affected by reward-related cues under different hormonal states, and the mechanism through which estradiol affects the incentive salience of these cues, is critically important to our understanding of motivation in the female rat. Experiments will use fast scan cyclic voltammetry to measure spontaneous DA release in the core and shell of the NAc during responding for a mate or food under different hormone conditions, using our novel paradigm to quantify female reproductive motivation. The role of DA in mediating the switch from choosing food to choosing a mate in the female will be determined. Graduate students and undergraduates will be involved in these studies. Findings will be disseminated through scientific publications as well as presentations at conferences at the local and national level. Specific activities for students in the laboratory included pre/post assessment of laboratory skills and development of a BrainsRule! presentation to local and Detroit middle school students about the neural mechanisms of motivation and choice.