Collaborative: ABI Development: Synthetic Biology Open Language Resource

协作：ABI 开发：合成生物学开放语言资源

• 批准号: 1356041
• 负责人: Chris Myers
• 金额: $ 44.45万
• 依托单位: University of Utah
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-07-01 至 2019-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1356041&HistoricalAwards=false
• 关键词: Collaborative; ABI; Development; Synthetic; Biology

The University of Washington and the University of Utah are awarded collaborative grants to develop and encourage the use of standards in the new engineering field of synthetic biology where biological systems are engineered to help manufacture drugs, biofuels, novel materials or more advanced applications such as new approaches to processing information. All engineering benefits from the use of standards. Examples include the standardization of screw and bolt sizes, standard voltages in computer electronic circuits, or internet standards that drive the World Wide Web. In each of these cases the use of standards has made many new industries economically viable which in turn has yielded enormous dividends to society. A nascent and growing community of synthetic biology researchers across industry and academia has come to recognize the value of standards, and worked together to develop the Synthetic Biology Open Language (SBOL), a standard that can describe biological designs constructed from DNA. This project will build from this starting place to (a) strengthen and extend SBOL so that it can serve a wider range of uses, (b) develop validation suites and services, so that systems can verify correct use of the standard, and (c) perform outreach and education to further grow and build our community of users and developers in both academia and industry. The key driving force for the development these standards will be the synthetic biology community. Our essential role is to put in place the means by which the whole community can benefit from a single standard that all can all agree to. The project also has in place a number of outreach efforts that will benefit society directly. At the educational level, a special relationship with a community driven effort called HiveBio (http://hivebio.org/) will help high school students and laypeople understand modern biotechnology and molecular biology through hands-on classes. Every year the project will help fund up to 30 individuals to learn about genetic engineering, the techniques that scientists use in the lab and the ethical issues that we potentially face in biotechnology. Two of the researchers on the project also publish undergraduate textbooks on synthetic biology and cellular modeling and will publish second editions of the books during the lifetime of the project. The project will hold biannual meetings where researchers from academia and industry will be able to discuss future developments for the standard and to further build the community. In addition to developing an active community website, the communities' work will be presented at workshops and cross-disciplinary groups engaged in work such as systems biology, and e-science. Project staff will also present at the Seattle science clubs where the general public can learn more about synthetic biology in general. The Synthetic Biology Open Language can be accessed at http://www.sbolstandard.org.

华盛顿大学和犹他州大学被授予合作赠款，以开发和鼓励在合成生物学的新工程领域使用标准，其中生物系统被工程化以帮助制造药物，生物燃料，新材料或更先进的应用，如处理信息的新方法。所有工程都得益于标准的使用。例子包括螺钉和螺栓尺寸的标准化，计算机电子电路中的标准电压，或驱动万维网的互联网标准。在每一种情况下，标准的使用都使许多新的行业在经济上可行，这反过来又给社会带来了巨大的红利。产业界和学术界的合成生物学研究人员已经认识到标准的价值，并共同开发了合成生物学开放语言（SBOL），这是一种可以描述从DNA构建的生物设计的标准。该项目将从这个起点开始，以（a）加强和扩展SBOL，使其能够服务于更广泛的用途，（B）开发验证套件和服务，使系统能够验证标准的正确使用，以及（c）进行推广和教育，以进一步发展和建立我们的学术界和工业界的用户和开发人员社区。开发这些标准的关键驱动力将是合成生物学界。我们的主要角色，是制订方法，使整个社会都能从一个大家都同意的单一标准中得益。该项目还开展了一些外联工作，将直接造福社会。在教育层面，与一个名为HiveBio的社区驱动的努力（http：//hivebio.org/）的特殊关系将帮助高中生和外行通过实践课程了解现代生物技术和分子生物学。每年，该项目将资助多达30人学习基因工程、科学家在实验室中使用的技术以及我们在生物技术中可能面临的伦理问题。 该项目的两名研究人员还出版了关于合成生物学和细胞建模的本科教科书，并将在项目期间出版这些书的第二版。 该项目将每年举行两次会议，来自学术界和工业界的研究人员将能够讨论该标准的未来发展，并进一步建立社区。 除了开发一个活跃的社区网站外，社区的工作将在研讨会和从事系统生物学和电子科学等工作的跨学科小组上介绍。项目工作人员还将出席西雅图科学俱乐部，在那里公众可以了解更多关于合成生物学的一般。合成生物学开放语言可以在http://www.sbolstandard.org上访问。

项目成果

Design of Asynchronous Genetic Circuits

• DOI: 10.1109/jproc.2019.2916057
• 发表时间: 2019-06
• 期刊: Proceedings of the IEEE
• 影响因子: 20.6
• 作者: Tramy Nguyen;Timothy S. Jones;P. Fontanarrosa;Jeanet V. Mante;Z. Zundel;D. Densmore;C. Myers