Collaborative Research: Plug and Play Photosynthesis for RuBisCO Independent Fuels
合作研究:RuBisCO 独立燃料的即插即用光合作用
基本信息
- 批准号:1359594
- 负责人:
- 金额:$ 46万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2014
- 资助国家:美国
- 起止时间:2014-06-01 至 2018-05-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Global human energy consumption is expected to increase by over 30% in the next 15 years. Although there is more than enough energy in sunlight to meet this challenge, efficient means to concentrate this diffuse solar energy and store it have not yet been developed. Photosynthesis is the biological process by which green plants and some microorganisms capture and store solar energy; they use it to convert carbon dioxide to metabolic fuels. However, photosynthesis is inherently an inefficient process; it is limited not by the availability of light from the sun but by the rate of the first step in the chemical reactions by which carbon dioxide is converted into products that are rich in energy. There is therefore unused capacity for the capture and use of solar energy by natural photosynthesis. This program engages teams of researchers from the US and the United Kingdom with the goal to re-invent photosynthesis with enhanced efficiency thereby improving the capacity of photosynthetic organisms to make renewable fuels and enhance food security. In the course of the scientific research, this project will provide research training opportunities for more than 14 people (including both women and underrepresented minorities) at the post-doctoral, graduate and undergraduate levels. The international and interdisciplinary nature of the project will build bridges between the US and UK scientific communities in a range of important scientific areas including synthetic biology, photosynthetic physiology, catalysis, and metabolic regulation. The researchers will engage and inform both the public and other investigators through activities that include peer-reviewed publications, public science lectures, blogs, websites, and popular science articles. To dramatically enhance the efficiency of photosynthesis, this project will develop a range of mechanisms to electrically connect light-activated electron flow from the photosynthetic reaction center (PSI) to downstream fuel-production pathways. This will include increasing flux through natural pathways, creating electrical connections between distinct microbial cell types by construction of artificial biological nanowires, and employing a soluble, chemical, redox shuttle to transfer reducing equivalents from a light harvesting cell to different fuel-producing cells. These scientific goals will be accomplished through four parallel specific aims. 1. Characterization of the components of (and mechanism for controlling flux through) the natural extracellular electron transfer pathway of the cyanobacterium Synechocystis. 2. Construction of artificial systems to abstract reducing equivalents from PSI; these will compete with natural electron acceptors only under highly reducing conditions. 3. Development of artificial means to move reducing equivalents out of the cytoplasm of Synechocystis. 4. Construction within microbes of artificial fuel-production modules that require only reducing equivalents and carbon dioxide as inputs. The project is highly interdisciplinary and will employ a range of techniques including those from microbiology, molecular biology, synthetic biology, biochemistry, electrochemistry, and protein and metabolic engineering.This award is supported jointly by the Cellular Dynamics and Function Cluster in the Division of Molecular and Cellular Biosciences and by the Biotechnology, Biochemical and Biomass Engineering Program in the Division of Chemical, Bioengineering, Environmental and Transport Systems.
预计未来15年,全球人类能源消费将增长30%以上。尽管阳光中有足够的能量来应对这一挑战,但还没有开发出有效的方法来集中这种弥漫的太阳能并将其储存起来。光合作用是绿色植物和一些微生物捕获和储存太阳能的生物过程;它们利用太阳能将二氧化碳转化为新陈代谢燃料。然而,光合作用本质上是一个低效的过程;它不是受到来自太阳的光的可获得性的限制,而是受到化学反应第一步的速度限制,通过这些反应,二氧化碳被转化为富含能量的产品。因此,存在通过自然光合作用捕获和利用太阳能的未使用能力。该项目邀请了来自美国和英国的研究团队,目标是以更高的效率重新发明光合作用,从而提高光合作用有机体制造可再生燃料的能力,并增强粮食安全。在科学研究过程中,该项目将为14多人(包括妇女和代表性不足的少数民族)提供博士后、研究生和本科生级别的研究培训机会。该项目的国际性和跨学科性质将在美国和英国科学界之间架起一座桥梁,涉及一系列重要科学领域,包括合成生物学、光合作用生理学、催化和代谢调节。研究人员将通过同行评议的出版物、公共科学讲座、博客、网站和科普文章等活动吸引公众和其他研究人员,并向他们提供信息。为了显著提高光合作用的效率,该项目将开发一系列机制,将光合作用反应中心(PSI)的光激活电子流电连接到下游的燃料生产路径。这将包括通过自然途径增加通量,通过构建人工生物纳米线在不同类型的微生物细胞之间建立电子连接,以及使用可溶的化学氧化还原穿梭将还原当量从捕光电池转移到不同的燃料产生电池。这些科学目标将通过四个平行的具体目标来实现。1.聚球藻天然胞外电子传递途径的组成及其调控机制的研究。2.构建从PSI中提取还原当量的人工系统;只有在高度还原的条件下,这些系统才能与天然电子受体竞争。3.开发将还原等效物移出聚球藻细胞质的人工方法。4.在微生物内建造人工燃料生产模块,只需要减少当量和二氧化碳作为投入。该项目是高度跨学科的,将采用一系列技术,包括微生物学、分子生物学、合成生物学、生物化学、电化学以及蛋白质和代谢工程。该奖项由分子和细胞生物科学部的细胞动力学和功能簇以及化学、生物工程、环境和运输系统部的生物技术、生化和生物质工程计划共同支持。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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David Kramer其他文献
Realizing a Proactive, Self-Optimizing System Behavior within Adaptive, Heterogeneous Many-Core Architectures
在自适应、异构众核架构中实现主动、自我优化的系统行为
- DOI:
10.1109/saso.2012.26 - 发表时间:
2012 - 期刊:
- 影响因子:0
- 作者:
David Kramer;Wolfgang Karl - 通讯作者:
Wolfgang Karl
Right-to-left Intrapulmonary Shunting Through Vascular Dilatations Contributes to Severe Hypoxemia in Patients With End-stage Pulmonary Fibrosis: Implications for Lung Transplantatio
- DOI:
10.1378/chest.124.4_meetingabstracts.201s - 发表时间:
2003-01-01 - 期刊:
- 影响因子:
- 作者:
Cesar A. Keller;Francisco Alvarez;Javier Aduen;David Kramer;Lawrence McBride;Octavio Pajaro; Lung Transplant Group - 通讯作者:
Lung Transplant Group
A Light-Weight Approach for Online State Classification of Self-organizing Parallel Systems
自组织并行系统在线状态分类的轻量级方法
- DOI:
10.1007/978-3-642-19137-4_16 - 发表时间:
2011 - 期刊:
- 影响因子:0
- 作者:
David Kramer;R. Buchty;Wolfgang Karl - 通讯作者:
Wolfgang Karl
Regional Cerebral Blood Flow and CO2 Reactivity in Fulminant Hepatic Failure
暴发性肝衰竭中的局部脑血流量和 CO2 反应性
- DOI:
- 发表时间:
1995 - 期刊:
- 影响因子:6.3
- 作者:
S. Durham;H. Yonas;S. Aggarwal;J. Darby;David Kramer - 通讯作者:
David Kramer
Information technology and social work education in the 1980s: three theses
20世纪80年代的信息技术和社会工作教育:三篇论文
- DOI:
10.1177/002087288703000204 - 发表时间:
1987 - 期刊:
- 影响因子:2.2
- 作者:
Hans;David Kramer - 通讯作者:
David Kramer
David Kramer的其他文献
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{{ truncateString('David Kramer', 18)}}的其他基金
ERA-CAPS: Collaborative Research: Thylakoid ion flux-Linking photosynthetic efficiency with osmotic stress response
ERA-CAPS:合作研究:类囊体离子通量-将光合效率与渗透胁迫响应联系起来
- 批准号:
1847193 - 财政年份:2018
- 资助金额:
$ 46万 - 项目类别:
Standard Grant
PAPM EAGER: A Plant Observatory for remote sensing of biochemical reactions in vivo
PAPM EAGER:遥感体内生化反应的植物观测站
- 批准号:
1758091 - 财政年份:2017
- 资助金额:
$ 46万 - 项目类别:
Standard Grant
PAPM EAGER: A Plant Observatory for remote sensing of biochemical reactions in vivo
PAPM EAGER:遥感体内生化反应的植物观测站
- 批准号:
1650196 - 财政年份:2016
- 资助金额:
$ 46万 - 项目类别:
Standard Grant
Collaborative Research: Plug and Play Photosynthesis for RuBisCO Independent Fuels
合作研究:RuBisCO 独立燃料的即插即用光合作用
- 批准号:
1104907 - 财政年份:2011
- 资助金额:
$ 46万 - 项目类别:
Standard Grant
Critical Roles of Transthylakoid Delta pH in the Energetics and Regulation of Photosynthesis
跨类囊体 Delta pH 在光合作用的能量学和调节中的关键作用
- 批准号:
9817980 - 财政年份:1999
- 资助金额:
$ 46万 - 项目类别:
Standard Grant
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- 批准号:10774081
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