SusChEM: Fluorinated Alkoxide Complexes of Copper for C-X Bond Forming Reactions

这项可持续化学、工程和材料项目的研究奖支持了波士顿大学Linda Doerrer教授的工作，该教授利用地球上丰富的金属铜开发新的C-X键形成反应。资助该提案对当地的影响将增加训练有素的年轻科学家的数量，他们可以在STEM领域接受教育和职业生涯，特别注重招聘和留住女性。一项新的双语推广计划正在设计中，这可能会影响波士顿地区以外的许多年轻学生。预计这项工作将对化学社区产生广泛的影响，因为这项工作使用了Cu，一种丰富且环境可持续的金属，可以在有或没有O2的情况下破坏C-H键，并形成各种新键。该策略使用铜来取代目前用于这些化学物质的昂贵且毒性更大的金属。开发化学键形成的新反应不仅需要考虑所需的产物，还需要考虑所形成的所有产物、过程的能量平衡以及总体环境成本。地球上丰富的金属是新的键形成工艺的极好候选者。在以前的工作中，一个新的具有可持续金属Fe， Co， Ni和Cu的分子家族被广泛开发。这些金属所含的配体实际上是被氟化基团覆盖的聚四氟乙烯，这使得它们高度抵抗非氟化分子可能遭受的分解反应。两个意想不到的和令人兴奋的发现提供了对正在追求的形成C-C， C-O和C-N键的常见反应的理解。这项工作的总体影响是为合成高价值碳基化合物的材料和方法提供了更好的理解，这些材料和方法可用于许多与社会相关的过程。

This Research award in the Sustainable Chemistry, Engineering, and Materials program supports work by Professor Linda Doerrer at Boston University to develop new C-X bond forming reactions with the earth-abundant metal copper. The local impact of funding this proposal will increase the number of well-trained young scientists that can pursue education and careers in STEM fields with a particular focus on recruiting and retaining women. A new bilingual outreach program is being designed which can potentially impact many young students outside the Boston area. A wide impact on the chemical community is envisaged as this work uses Cu, an abundant and environmentally sustainable metal, to break C-H bonds, with and without O2, and make a variety of new bonds. The strategy uses copper to replace the expensive and more toxic metals currently used for these chemistries. Developing new reactions for chemical bond formation requires considering not only the desired product, but all the products formed, the energy balance of the process, as well as the overall environmental cost. Earth-abundant metals are excellent candidates for new bond forming processes. In previous work, a new family of molecules with the sustainable metals Fe, Co, Ni, and Cu was extensively developed. The metals contained ligands that are effectively teflon-coated with fluorinated groups that make them highly resistant to decomposition reactions that non-fluorinated molecules can be prey to. Two unexpected and exciting discoveries made with Cu provide an understanding for common reactions forming C-C, C-O, and C-N bonds that are being pursued. The overall impact of this work is to provide an improved understanding of materials and methods for synthesizing high value carbon-based compounds for use in numerous processes of societal relevance.