SusChEM: Fluorinated Alkoxide Complexes of Copper for C-X Bond Forming Reactions

这项可持续化学、工程和材料项目的研究奖支持波士顿大学琳达·多勒教授的工作，以开发新的C-X键与地球上丰富的金属铜形成反应。资助这一提案的地方影响将增加训练有素的年轻科学家的数量，他们可以在STEM领域接受教育和从事职业，特别注重招聘和留住女性。一个新的双语推广计划正在设计中，这可能会影响波士顿地区以外的许多年轻学生。预计这项工作将对化学界产生广泛的影响，因为这项工作使用铜，一种丰富的和环境可持续的金属，在有和没有O2的情况下打破C-H键，并产生各种新的键。该战略使用铜来取代目前用于这些化学品的昂贵且毒性更大的金属。 开发化学键形成的新反应不仅需要考虑所需的产物，还需要考虑形成的所有产物、过程的能量平衡以及整体环境成本。地球上丰富的金属是新的键形成过程的绝佳候选者。在以前的工作中，广泛开发了具有可持续金属Fe，Co，Ni和Cu的新分子家族。这些金属含有配体，这些配体有效地用氟化基团涂覆聚四氟乙烯，使它们对非氟化分子可能被捕食的分解反应具有高度抵抗性。两个意想不到的和令人兴奋的发现与铜提供了一个共同的反应，形成C-C，C-O和C-N键正在追求的理解。这项工作的总体影响是提供了一个更好的理解材料和方法，用于合成高价值的碳基化合物，用于许多社会相关的过程。

This Research award in the Sustainable Chemistry, Engineering, and Materials program supports work by Professor Linda Doerrer at Boston University to develop new C-X bond forming reactions with the earth-abundant metal copper. The local impact of funding this proposal will increase the number of well-trained young scientists that can pursue education and careers in STEM fields with a particular focus on recruiting and retaining women. A new bilingual outreach program is being designed which can potentially impact many young students outside the Boston area. A wide impact on the chemical community is envisaged as this work uses Cu, an abundant and environmentally sustainable metal, to break C-H bonds, with and without O2, and make a variety of new bonds. The strategy uses copper to replace the expensive and more toxic metals currently used for these chemistries. Developing new reactions for chemical bond formation requires considering not only the desired product, but all the products formed, the energy balance of the process, as well as the overall environmental cost. Earth-abundant metals are excellent candidates for new bond forming processes. In previous work, a new family of molecules with the sustainable metals Fe, Co, Ni, and Cu was extensively developed. The metals contained ligands that are effectively teflon-coated with fluorinated groups that make them highly resistant to decomposition reactions that non-fluorinated molecules can be prey to. Two unexpected and exciting discoveries made with Cu provide an understanding for common reactions forming C-C, C-O, and C-N bonds that are being pursued. The overall impact of this work is to provide an improved understanding of materials and methods for synthesizing high value carbon-based compounds for use in numerous processes of societal relevance.