Scope and Applications of Amide Ligation of Hydroxyamines

羟胺酰胺连接的范围和应用

• 批准号: 1362737
• 负责人: Michael Pirrung
• 金额: $ 45万
• 依托单位: University of California-Riverside
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-07-01 至 2018-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1362737&HistoricalAwards=false
• 关键词: Scope; Applications; Amide; Ligation; Hydroxyamines

With this New award, the Chemical Synthesis Program supports Professor Michael C. Pirrung of the University of California-Riverside in a project investigating reactions that add an amino acid to a peptide chain, thus extending the chain. Three different amino acids will be employed in these reactions, which build peptide chains. This project focuses on broadening the methods available for building peptides and proteins. Such reactions are of far reaching importance in diverse areas of organic and biological chemistry. Hence, these methods will expand the synthetic toolboxes of a wide range of researchers in the biomedical sciences. This project will also provide training in organic synthesis and peptide chemistry to students, from undergraduates to post-doctorals, including those from groups historically underrepresented in the sciences.The project will study peptide bond forming reactions between serine and mildly activated C-terminal peptide esters. These reactions, which will be extended to threonine and homoserine, will expand the scope of peptide forming reactions and help to alleviate problems of concentration and scalability. The viability of the method will be tested through the synthesis of naturally occurring peptide sequences.

有了这个新的奖项，化学合成计划支持教授迈克尔C。Pirrung博士在一个项目中研究了将氨基酸添加到肽链上从而延长肽链的反应。在这些反应中将使用三种不同的氨基酸，它们构建肽链。该项目的重点是扩大可用于构建肽和蛋白质的方法。这些反应在有机化学和生物化学的不同领域具有深远的重要性。因此，这些方法将扩展生物医学科学中广泛研究人员的合成工具箱。该项目还将为学生提供有机合成和肽化学方面的培训，从本科生到博士后，包括历史上在科学领域代表性不足的群体。该项目将研究丝氨酸和轻度活化的C-末端肽酯之间的肽键形成反应。这些反应将扩展到苏氨酸和高丝氨酸，将扩大肽形成反应的范围，并有助于减轻浓度和可扩展性的问题。将通过合成天然存在的肽序列来检测该方法的可行性。