Magneto-mechanical Sensors and Actuators for Platelet Biomechanics under Flow

用于流动下血小板生物力学的磁机械传感器和执行器

• 批准号: 1402673
• 负责人: Nathan Sniadecki
• 金额: $ 29.99万
• 依托单位: University of Washington
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-06-01 至 2018-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1402673&HistoricalAwards=false
• 关键词: Magneto; mechanical; Sensors; Actuators; Platelet

This project will investigate the physics of blood clotting. It will elucidate the role of platelet forces and viscoelasticity during clot formation and will establish a translational tool that can generate biomechanical-specific data on platelets. The project will enable a greater understanding of the coagulation process beyond the classical coagulation cascade. It will not only advance the fields of hemostasis and thrombosis, but also biomechanics, nanomaterials, and nanomagnetics. The educational plan focuses on integrating research concepts into courses on biomechanics at the awardee's institution as well as organizing K-12 and undergraduate outreach events that focus on research opportunities. The research and educational plans provide training experience for future generations in nanoscale biomechanics and biotechnology by involving graduate students and undergraduate students in the research.The research objective of this award is to develop a microfluidic platform that can test the biomechanical properties of platelets and measure their contractile forces during clotting. Platelets are the smallest cells in the human body, but are indispensable in hemostasis. In clot formation, the platelet cytoskeleton is necessary for changing cell shape and for producing actin-myosin forces. The first task of this award will work to fabricate strong magnetic nanowires by increasing the size and improving the composition of the nanowires. The second task will work to embed nanowires into microposts inside a microfluidic device so that an external magnetic field can be used to apply forces to platelets. The third task will work to build nanoscale magnetometers underneath each magnetic micropost to measure their deflection by platelet forces.

这个项目将研究血液凝固的物理原理。它将阐明血小板力和粘弹性在凝块形成过程中的作用，并将建立一个翻译工具，可以生成血小板的生物力学特异性数据。该项目将使人们能够更好地理解混凝过程，而不仅仅是经典的混凝级联。它不仅将推动止血和血栓领域的发展，而且将推动生物力学、纳米材料和纳米磁学领域的发展。该教育计划的重点是将研究概念整合到获奖者所在机构的生物力学课程中，并组织以研究机会为重点的K-12和本科生外展活动。研究和教育计划通过让研究生和本科生参与研究，为未来几代人提供纳米尺度生物力学和生物技术的培训经验。该奖项的研究目标是开发一种微流体平台，可以测试血小板的生物力学特性，并测量它们在凝血过程中的收缩力。血小板是人体内最小的细胞，但在止血中不可或缺。在凝块形成过程中，血小板细胞骨架对于改变细胞形状和产生肌动蛋白-肌球蛋白力是必需的。该奖项的第一项任务将是通过增加纳米线的尺寸和改善纳米线的组成来制造强磁性纳米线。第二项任务是将纳米线嵌入微流体装置的微柱中，这样就可以利用外部磁场对血小板施加力。第三项任务是在每个磁微柱下面建造纳米级的磁力计，以测量它们在血小板力作用下的偏转。

项目成果

A microfluidic approach for hemoglobin detection in whole blood

• DOI: 10.1063/1.4997185
• 发表时间: 2017-10-01
• 期刊: AIP ADVANCES
• 影响因子: 1.6
• 作者: Taparia, Nikita;Platten, Kimsey C.;Sniadecki, Nathan J.
• 通讯作者: Sniadecki, Nathan J.