EAPSI: Characterization of new materials to advance separations technology

EAPSI：新材料表征以推进分离技术

• 批准号: 1414747
• 负责人: Jesse Hyslop
• 金额: $ 0.51万
• 依托单位: Hyslop Jesse S
• 依托单位国家: 美国
• 项目类别: Fellowship Award
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-06-01 至 2015-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1414747&HistoricalAwards=false
• 关键词: EAPSI; Characterization; new; materials; advance

The ability to separate and analyze a specific compound from a mixture enables scientists to make crucial discoveries that advance their science. Separations of compounds are used in all chemical and biological sciences, as well as engineering. One important technique for these separations is Electrokinetic Chromatography (EKC). This is an analytical technique that provides fast separations of minute amounts of sample through the use of an electric potential across a solution. This specific research will synthesize new materials that provide unique separation properties and improved performance within EKC. This research will be conducted in collaboration with Dr. Emily Hilder, an eminent scientist in the field of separation science at the Australian Center for Research on Separation Science (ACROSS). As one of the premier centers for separation science research in the world, ACROSS provides the infrastructure needed to demonstrate the performance of latex nanoparticles (NP), the solid substructure within the EKC separation column. This collaborative work will provide a critical step in bringing advances in EKC to the separations community. This work will utilize advanced CE-ESI-MS instrumentation at ACROSS to achieve the high detection sensitivity required, and to demonstrate ESI interface compatibility. The NP PSPs performance will be characterized with Linear Solvation Energy Relationship (LSER) models to understand the effects of NP structure on selectivity and mobility. The LSER data will provide a fundamental understanding of the effects of NP size and chemistry on methylene selectivity and retention factors. This will provide the data needed to guide the engineering of NP PSPs for specific applications. In addition, the PSPs will be used in current research applications to illustrate NP PSP applicability to cutting edge challenges that are not addressed by existing separations technology. This NSF EAPSI award is funded in collaboration with the Australian Academy of Science.

从混合物中分离和分析特定化合物的能力使科学家能够做出推动科学发展的关键发现。化合物的分离用于所有化学和生物科学以及工程。用于这些分离的一种重要技术是电动色谱（EKC）。这是一种分析技术，通过使用溶液中的电势来快速分离微量样品。这项具体的研究将合成新材料，提供独特的分离性能和改善EKC的性能。这项研究将与澳大利亚分离科学研究中心（ACROSS）分离科学领域的杰出科学家艾米丽希尔德博士合作进行。作为世界上最重要的分离科学研究中心之一，ACROSS提供了展示乳胶纳米颗粒（NP）性能所需的基础设施，乳胶纳米颗粒是EKC分离柱内的固体子结构。这一合作将是将环境知识中心的进展带给离职界的关键一步。 这项工作将利用先进的CE-ESI-MS仪器在ACROSS实现所需的高检测灵敏度，并证明ESI接口的兼容性。NP PSP的性能将通过线性溶剂化能量关系（LSER）模型来表征，以了解NP结构对选择性和迁移率的影响。的LSER数据将提供一个基本的了解NP大小和化学对亚甲基的选择性和保留因子的影响。这将为指导NP PSP的工程设计提供所需的数据。此外，PSP将用于当前的研究应用，以说明NP PSP适用于现有分离技术无法解决的前沿挑战。这个NSF EAPSI奖是与澳大利亚科学院合作资助的。