SBIR Phase I: Low-Cost and Sample-Efficient Micromachined Ultrasonic Sensor for Blood Coagulation Time Monitoring

SBIR 第一阶段：用于凝血时间监测的低成本且高效采样的微机械超声波传感器

• 批准号: 1416473
• 负责人: Jonathan Gonzales
• 金额: $ 15万
• 依托单位: IntegSense Inc.
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-07-01 至 2015-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1416473&HistoricalAwards=false
• 关键词: SBIR; Phase; Low; Cost; Sample

The broader impact/commercial potential of this project is in enabling a novel and powerful diagnostic technique that could open the door to emergence of a new class of micro-scale ultrasonic characterization devices. The immediate impact of the project is in the field of biomedical sensors and aims at increasing the accessibility and affordability of health care for our aging population. Access to simple and accurate Point of Care devices such as those developed in this project can greatly drive down the cost of health care while ensuring a healthier society. This is especially important for the current time where the cost of healthcare is a becoming an increasing burden for families, government and healthcare industry. In addition, the technology developed in this project has potential to be modified for use in other industries, such as measuring viscosity of precious materials. If successful, the technology can be licensed for use in several other products to greatly increase its economic impact.This Small Business Innovation Research (SBIR) Phase I project aims at studying the feasibility of utilizing a micro-scale ultrasonic liquid sensor for measuring the coagulation time of very small volumes of blood (less than 1µL). If successful, this innovative sensor technology will be the basis for an accurate and affordable Point of Care (POC) blood coagulation monitoring system. A need exists in the field of medical diagnostics for an electronic device able to measure blood coagulation, which is sufficiently inexpensive, reliable and convenient to use, and that permits points-of-care use by untrained individuals or health professionals in locations such as the home, medical emergency sites, and battlefields. These devices also need to operate with a sample sizes as small as practically possible. Micro-resonant sensors are a viable solution and offer many advantages such as quasi-digital outputs, simple electronics interface, small size, and high sensitivities. However, the application of such resonant sensors for measuring biofluids has been limited due to the inherent dampening of the resonant structure when operated in liquid environments such as blood. The proposed sensor in this proposal will achieve the ease of electronic interfacing while maintaining high performance when measuring viscose liquid properties.

该项目的更广泛的影响/商业潜力在于实现一种新颖而强大的诊断技术，这可能为新型微尺度超声表征设备的出现打开大门。该项目的直接影响是在生物医学传感器领域，其目的是增加我国老龄化人口获得和负担得起医疗保健的机会。获得简单而准确的护理点设备，例如在这个项目中开发的设备，可以大大降低医疗保健的成本，同时确保社会更健康。这一点在当前尤为重要，因为医疗保健成本正成为家庭、政府和医疗保健行业日益沉重的负担。此外，在这个项目中开发的技术有潜力被修改用于其他行业，如测量珍贵材料的粘度。如果成功，该技术可以被授权用于其他几种产品，以大大增加其经济影响。这个小企业创新研究（SBIR）一期项目旨在研究利用微型超声波液体传感器测量非常小体积血液（小于1 μ L）凝固时间的可行性。如果成功，这种创新的传感器技术将成为准确和负担得起的护理点（POC）血液凝固监测系统的基础。医疗诊断领域需要一种能够测量血液凝固的电子设备，这种设备足够便宜、可靠和方便使用，并且允许未经培训的个人或卫生专业人员在家庭、医疗急救地点和战场等地点使用。这些设备还需要在尽可能小的样本量下运行。微谐振传感器是一种可行的解决方案，具有准数字输出、电子接口简单、体积小、灵敏度高等优点。然而，由于谐振结构在血液等液体环境中工作时固有的阻尼性，这种谐振传感器用于测量生物流体的应用受到了限制。本提案中提出的传感器将实现电子接口的便利性，同时在测量粘胶液体特性时保持高性能。