Investigation of nesfatin-1 as a peptide product of the gastric X/A-like cell on anxiety behavior in animals and humans.

研究 nesfatin-1 作为胃 X/A 样细胞的肽产物对动物和人类焦虑行为的影响。

• 批准号: 216245554
• 负责人: Professor Dr. Andreas Stengel
• 金额: --
• 依托单位: Abteilung für Psychosomatische Medizin und Psychotherapie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2012
• 资助国家: 德国
• 起止时间: 2011-12-31 至 2016-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/216245554?language=en
• 关键词: Investigation; nesfatin; peptide; product; gastric

This project will focus on a peptide hormone that is not only involved in the regulation of food intake (as a so called satiety hormone) but also plays a role in the stress axis. Recent studies showed that this hormone, nesfatin-1, has an anxiogenic effect in animals and also shows an association with anxiety in humans. The studies proposed here will further investigate the topic of the role of nesfatin-1, predominantly the acute regulation, in the mediation of anxiety in animals and humans.

该项目将重点研究一种不仅参与食物摄取调节(作为一种所谓的饱腹感荷尔蒙)，而且在应激轴中发挥作用的多肽荷尔蒙。最近的研究表明，这种名为Nesfatin-1的激素在动物中具有引发焦虑的作用，也显示出与人类的焦虑有关。这里提出的研究将进一步研究Nesfatin-1在动物和人类焦虑调节中的作用，主要是急性调节。