Exploring the effects of nesfatin-1 in reward-associated and compulsive-like eating (B05 [A05])

肽nesfatin-1在中枢神经系统以及外周中具有多效性功能。Nesfatin-1在与能量摄入和消耗的稳态调节相关的大脑区域中高度表达，但也在与奖励相关的回路中表达。重要的是，我们可以表明，nesfatin-1的中央管理减少“喜欢”和“想要”，这表明对中脑边缘多巴胺能系统的抑制作用。在这个项目中，我们的目的是调查的作用，内源性nesfatin-1和招聘催产素系统使用综合行为，药理学和分子/遗传学的方法。我们假设，nesfatin-1敲低奖励相关领域将增加美味食物的奖励价值，从而加强享乐系统的激活，从而有助于饮食失调的发病。

The peptide nesfatin-1 possesses pleiotropic functions in the central nervous system as well as in the periphery. Nesfatin-1 is highly expressed in brain regions relevant for the homeostatic regulation of energy intake and expenditure, but also in reward-related circuits. Importantly, we could show that central administration of nesfatin-1 reduces “liking” and “wanting”, suggesting an inhibitory influence on the mesolimbic dopaminergic system. In this project, we aim at investigating the role of endogenous nesfatin-1 and the recruitment of the oxytocin system using an integrative behavioural, pharmacological and molecular/genetic approach. We hypothesize that nesfatin-1 knockdown in reward-related areas would increase the reward value of palatable food and therefore potentiate the activation of the hedonic system, thus contributing to the onset of eating disorders.