Houseplants Genetically Modified for Degradation of Common Carcinogenic Indoor Air Pollutants

用于降解常见致癌室内空气污染物的转基因室内植物

• 批准号: 1438266
• 负责人: Stuart Strand
• 金额: $ 33.4万
• 依托单位: University of Washington
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-10-01 至 2017-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1438266&HistoricalAwards=false
• 关键词: Houseplants; Genetically; Modified; Degradation; Common

1438266 (Strand). Home air can contain gaseous carcinogens at levels that exceed health standards for indoor environments. This project will transform a common houseplant with genes normally expressed in mammals, that are involved in the detoxification of air pollutants, including benzene, dichlorobenzene, chloroform, and acrolein, and with bacterial genes for the degradation of formaldehyde. These transgenic houseplants are expected to have the capability to help decrease the levels of carcinogens common in indoor air. The investigators will test the plants' efficacy under ambient conditions and their biosafety. This project will add to the arsenal of methods for decreasing carcinogens in the home, which make up a significant fraction of human exposures to cancer risk. This research will also clarify the widely varying rates observed by labs working on houseplant effects on air borne pollutants.The project will introduce students and faculty to important techniques that are relatively new to the environmental engineering field. Results will be disseminated by presentations at national and international environmental engineering conferences. A web site will be prepared to showcase the results of the project. Underrepresented groups at the K-12 and undergraduate level will be reached through the minority science and engineering program, MESP, and the mathematics, science, engineering achievement program, MESA, at the University of Washington.

1438266（斯特兰德）。家庭空气中可能含有超过室内环境健康标准的气态致癌物。该项目将改造一种常见的室内植物，使其具有通常在哺乳动物中表达的基因，这些基因参与空气污染物的解毒，包括苯，二氯苯，氯仿和丙烯醛，以及降解甲醛的细菌基因。这些转基因室内植物有望有助于降低室内空气中常见的致癌物质水平。研究人员将测试这些植物在环境条件下的功效及其生物安全性。该项目将增加减少家庭致癌物的方法库，这些致癌物构成了人类接触癌症风险的重要部分。这项研究还将阐明室内植物对空气污染物影响的实验室观察到的广泛变化率。该项目将向学生和教师介绍环境工程领域相对较新的重要技术。结果将通过在国家和国际环境工程会议上发表演讲来传播。将建立一个网站，展示该项目的成果。 在K-12和本科水平的代表性不足的群体将通过少数民族科学和工程计划，MESP，和数学，科学，工程成就计划，梅萨，在华盛顿大学达到。