Collaborative Research: SCH: A wireless optoelectronic implant for closed-loop control of bi-hormone secretion from genetically modified islet organoid grafts

合作研究：SCH：一种无线光电植入物，用于闭环控制转基因胰岛类器官移植物的双激素分泌

• 批准号: 2306708
• 负责人: Wen Li
• 金额: $ 84万
• 依托单位: Michigan State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-01 至 2027-07-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2306708&HistoricalAwards=false
• 关键词: Collaborative; Research; SCH; wireless; optoelectronic

Type 1 diabetes (T1D) is a chronic autoimmune disease that affects 1.5 million Americans and 20–40 million people worldwide. While a broad understanding of T1D has been gained over the past few decades, a cure for T1D is still not available. Researchers at Michigan State University and the University of Texas at Austin are collaborating to develop a novel framework for continuous, precise, and closed-loop control of bi-hormone (insulin or glucagon) secretion, using tiny wireless optoelectronic implants. This research is the first attempt to use optogenetic tools, using an array of highly efficient, implantable, Wireless (untethered and battery-free) OptoElectronic Implants (WOEIs) with a negligible footprint and minimal invasiveness to control bi-hormone secretion from islet organoids. This approach should pave the way for developing a new technological therapy for T1D. The direct benefits to millions of affected individuals worldwide include improved quality of life and reduced cost of associated medical care.The overarching goal of this project is to develop a closed-loop framework for rapid, selective, and precise control of bi-hormone secretion from genetically modified islet organoid grafts, using highly efficient, implantable WOEIs. The WOEI will monolithically integrate a dual-color optical stimulator and an optical glucose sensor with a wireless system-on-chip in an ultra-small and lightweight package. A distributed array of such WOEIs can simultaneously control many islet organoids for large volumetric coverage and better uniformity. A wireless backpack worn by the animal will carry highly efficient wireless electronics for safe power transfer from a wireless power cage to the WOEIs, and wideband data communication with the WOEIs and with the end-user. An interactive user interface hosted on a personal device (i.e., personal computer, smartphone, etc.) will receive and analyze glucose-sensing data in real-time and control optogenetic modulation in a closed-loop manner. This project is multidisciplinary and will significantly impact research and technological development in biomedical devices, stem cell biology, and wireless microelectronics. Furthermore, this project is expected to have a broad impact on engineering-/health-related STEM education through the integration of research with diverse educational and outreach activities, such as project demos/field tours, graduate and undergraduate research, teacher training, K-12 curricula, new course components, social media, and YouTube programs. These efforts will collectively benefit the broader society by providing effective personalized therapies for T1D management, engaging significant underserved populations, promoting biomedical research for personalized medicine, and training the US STEM workforce.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

1型糖尿病（T1D）是一种慢性自身免疫性疾病，在全球范围内影响150万美国人和20-40万人。尽管在过去的几十年中，人们对T1D有了广泛的了解，但仍无法使用T1D的治疗方法。密歇根州立大学和德克萨斯大学奥斯汀分校的研究人员正在合作开发一个新颖的框架，以使用微小的无线光电发式即兴即兴创作，以连续，精确和闭环控制双激素（胰岛素）或胰高血糖素）分泌。这项研究是使用光遗传学工具的首次尝试，使用一系列高效，可植入，无线（不受限制的电池和无电池）光电植入物（WOEIS），具有可忽略不计的足迹和微不足道的侵入性来控制胰岛类动物的生物激素分泌。这种方法应该为开发T1D的新技术疗法铺平道路。全世界数百万个受影响的人的直接好处包括改善的生活质量和相关医疗服务的成本降低。该项目的总体目标是使用高效，植入式的耐毒药从转基因修饰的胰岛类器官植物中开发出快速，选择性和精确控制双激素分泌的闭环框架。 WOEI将单层整合双色光刺激器和一个光学葡萄糖传感器，并在超小和轻量级的包装中使用无线芯片进行芯片。这样的魔鬼的分布阵列可以简单地控制许多胰岛类器官，以获得大量的覆盖范围和更好的均匀性。动物穿着的无线背包将携带高效的无线电子设备，以从无线电源笼到魔杖，以及与Woeis和最终用户的宽带数据通信。在个人设备上托管的交互式用户界面（即个人计算机，智能手机等）将以闭环方式实时接收和分析葡萄糖感应数据。该项目是多学科的，将显着影响生物医学设备，干细胞生物学和无线微电子学的研究和技术开发。此外，通过将研究与多元化教育和外展活动相结合，例如项目演示/实地考察，研究生和本科研究，教师培训，K-12课程，新课程组件，新课程组件，社交媒体和YouTube计划，预计该项目将对工程/健康相关的STEM教育产生广泛的影响。这些努力将通过为T1D管理提供有效的个性化疗法，吸引大量服务不足的人群，促进生物医学研究，并培训美国STEM劳动力。该奖项反映了NSF的法定任务，并通过使用该基金会的知识分子优点和广泛的影响来评估NSF的支持。