Fast temporal processing and ,central auditory disorder`: subcortical mechanisms

快速时间处理和中枢听觉障碍：皮层下机制

• 批准号: 218325849
• 负责人: Professor Dr. Andrej Kral
• 金额: --
• 依托单位: Verbundinstitut für AudioNeurotechnologie und Nanobiomaterialien (VIANNA)
• 依托单位国家: 德国
• 项目类别: Priority Programmes
• 财政年份: 2012
• 资助国家: 德国
• 起止时间: 2011-12-31 至 2014-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/218325849?language=en
• 关键词: Fast; temporal; processing; central; auditory

The ability to follow the temporal structure of sounds at high frequencies is required for discrimination of complex sounds and sound localization. The central auditory disorder (CAPD) is characterized by normal cochlear thresholds, but affected recognition, discrimination, separation, grouping, localization or ordering of sounds. To investigate the pathophysiology of CAPD and develop a clinically-exploitable method for differential diagnosis of the causes, transgenic mice with an induced Cav1.3-deficiency in the brainstem will be used. Preliminary results show that these animals have normal hearing thresholds, abnormal brainstem evoked responses (ABRs) and structural changes in the brainstem, corresponding to the definition of CAPD. In the present project, responses of neurons to simple tones, complex sounds and binaural stimuli will be investigated in the inferior colliculus of these animals. The inferior colliculus is the most central auditory structure showing a high precision in temporal synchrony with the acoustic input and receiving inputs from the structures affected in the transgenic animals used. We want to test the ability of neurons to follow the temporal envelope of the sounds. Also, the cues of azimuthal locations will be investigated. Finally, ABRs will be recorded during stimulation with temporally complex sounds. After determining the neuronal signature of the deficit in the midbrain, a stimulus will be designed that can allow to detect the described deficits using ABRs in human subjects.

在高频率下遵循声音的时间结构的能力是区分复杂声音和声音定位所必需的。中枢性听觉障碍（CAPD）的特征是耳蜗阈值正常，但对声音的识别、辨别、分离、分组、定位或排序受到影响。为了研究CAPD的病理生理学并开发用于病因鉴别诊断的临床可利用的方法，将使用脑干中具有诱导Cav1.3缺陷的转基因小鼠。初步结果表明，这些动物具有正常的听阈，异常的脑干诱发反应（ABR）和脑干结构的变化，对应于CAPD的定义。在本项目中，神经元对简单的声音，复杂的声音和双耳刺激的反应将在这些动物的下丘进行研究。下丘是最中心的听觉结构，其在与声输入的时间同步方面显示出高精度，并且接收来自所使用的转基因动物中受影响的结构的输入。我们想测试神经元跟随声音的时间包络的能力。此外，方位角位置的线索将被调查。最后，将在使用时间复杂声音的刺激期间记录ABR。在确定中脑中缺陷的神经元特征之后，将设计刺激，其可以允许使用人类受试者中的ABR检测所描述的缺陷。