CAREER: Novel Methods for the Stereoselective Synthesis of Nitrogen Containing Heterocycles

凭借这一职业奖，化学合成项目正在支持北卡罗来纳州立大学 Joshua G. Pierce 教授的研究。皮尔斯教授将开发合成含氮杂环的新方法。 该研究的一方面允许有效地制备密集功能化的噻唑啉，为化学合成提供独特的氮自由基前体。 第二个研究工作是构建吡咯烷的不对称方法，吡咯烷是复杂天然产物中常见的杂环化合物。 皮尔斯教授正在与北卡罗来纳州罗利的自然科学博物馆合作，为公众开设一系列科学咖啡馆。该合作伙伴关系还涉及一个交互式“合成实验室”，以吸引 K-12 学生学习有机化学和化学生物学。 Pierce 教授是北卡罗来纳州立大学 SEED 项目学生和 NSF REU 学生的导师。

With this CAREER award, the Chemistry Synthesis program is supporting the research of Professor Joshua G. Pierce of North Carolina State University. Professor Pierce will develop new methodologies for the synthesis of nitrogen-containing heterocycles. One aspect of the research allows efficient approaches to densely functionalized thiazolines providing unique nitrogen radical precursors for chemical synthesis. A second research endeavor is asymmetric approaches for the construction of pyrrolidines, heterocycles commonly found in complex natural products. Professor Pierce is engaged in a collaboration with the Natural Sciences Museum in Raleigh, NC involving a series of Science Cafes for the general public. The partnership also involves an interactive "synthesis lab" to engage K-12 students in organic chemistry and chemical biology. Professor Pierce is a mentor for Project SEED students and NSF REU students at North Carolina State University.