CAREER: Novel Methods for the Stereoselective Synthesis of Nitrogen Containing Heterocycles

有了这个CAREER奖，化学合成项目支持了北卡罗来纳州立大学的Joshua G. Pierce教授的研究。皮尔斯教授将开发合成含氮杂环化合物的新方法。该研究的一个方面允许有效的方法来密集功能化噻唑类，为化学合成提供独特的氮自由基前体。第二项研究是用不对称的方法来构造吡咯烷，吡咯烷是复杂天然产物中常见的杂环。皮尔斯教授正在与北卡罗来纳州罗利的自然科学博物馆合作，为公众提供一系列科学咖啡馆。合作还包括一个互动的“合成实验室”，让K-12学生参与有机化学和化学生物学。皮尔斯教授是北卡罗莱纳州立大学SEED项目学生和NSF REU学生的导师。

With this CAREER award, the Chemistry Synthesis program is supporting the research of Professor Joshua G. Pierce of North Carolina State University. Professor Pierce will develop new methodologies for the synthesis of nitrogen-containing heterocycles. One aspect of the research allows efficient approaches to densely functionalized thiazolines providing unique nitrogen radical precursors for chemical synthesis. A second research endeavor is asymmetric approaches for the construction of pyrrolidines, heterocycles commonly found in complex natural products. Professor Pierce is engaged in a collaboration with the Natural Sciences Museum in Raleigh, NC involving a series of Science Cafes for the general public. The partnership also involves an interactive "synthesis lab" to engage K-12 students in organic chemistry and chemical biology. Professor Pierce is a mentor for Project SEED students and NSF REU students at North Carolina State University.