CAREER: Novel Methods for the Stereoselective Synthesis of Nitrogen Containing Heterocycles

职业：立体选择性合成含氮杂环的新方法

• 批准号: 1454845
• 负责人: Joshua Pierce
• 金额: $ 67.5万
• 依托单位: North Carolina State University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-07-01 至 2020-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1454845&HistoricalAwards=false
• 关键词: CAREER; Novel; Methods; Stereoselective; Synthesis

With this CAREER award, the Chemistry Synthesis program is supporting the research of Professor Joshua G. Pierce of North Carolina State University. Professor Pierce will develop new methodologies for the synthesis of nitrogen-containing heterocycles. One aspect of the research allows efficient approaches to densely functionalized thiazolines providing unique nitrogen radical precursors for chemical synthesis. A second research endeavor is asymmetric approaches for the construction of pyrrolidines, heterocycles commonly found in complex natural products. Professor Pierce is engaged in a collaboration with the Natural Sciences Museum in Raleigh, NC involving a series of Science Cafes for the general public. The partnership also involves an interactive "synthesis lab" to engage K-12 students in organic chemistry and chemical biology. Professor Pierce is a mentor for Project SEED students and NSF REU students at North Carolina State University.

有了这个职业奖，化学合成项目将支持北卡罗来纳州立大学的乔舒亚·G·皮尔斯教授的研究。皮尔斯教授将开发合成含氮杂环的新方法。这项研究的一个方面是提供高效的方法，为化学合成提供独特的氮自由基前驱体。第二个研究努力是构建吡咯烷的不对称方法，吡咯烷是复杂天然产品中常见的杂环化合物。皮尔斯教授正在与北卡罗来纳州罗利市的自然科学博物馆合作，为公众提供一系列科学咖啡馆。这项合作还包括一个互动的“合成实验室”，让K-12年级的学生学习有机化学和化学生物学。皮尔斯教授是北卡罗来纳州立大学的项目种子学生和NSF REU学生的导师。