CAREER: Copper Catalyzed Oxidative Decarboxylative Coupling Reactions for the Direct Functionalization of Arenes

在这个由化学部化学催化项目资助的项目中，西弗吉尼亚大学的Jessica Hoover教授正在开发新的催化反应，通过氧化脱羧偶联反应从羧酸形成碳-碳（C-C）键。这种新方法利用铜催化剂将简单的羧酸和芳烃转化为与制药和生物分子相关的杂二芳和卤代烷基芳烃。该技术对经典的耦合方法进行了改进，包括用廉价且易得的羧酸起始材料取代昂贵、有毒和浪费的有机金属试剂，同时产生最小的浪费。C-C键的形成是构建复杂结构的关键步骤，该方法的成功开发将使制药和精细化工行业能够设计出新的、更有效的C-C键形成催化剂。胡佛教授积极参与本科生水平的研究和教育的整合，部分是通过让本科生参与研究实验室，部分是通过将研究实验和概念纳入本科课程。该奖项还支持一个新的夏季项目的发展，该项目旨在将化学家、工程师和艺术家聚集在一起，为建立一个公共科学艺术装置的共同目标而努力。该项目旨在在摩根敦当地社区发起有意义的科学对话，帮助学生参与者在科学、人文和艺术以及更广泛的公共领域之间进行有效的交流。

In this project funded by the Chemical Catalysis program of the Chemistry Division, Professor Jessica Hoover of West Virginia University is developing new catalytic reactions for the formation of carbon-carbon (C-C) bonds from carboxylic acids through oxidative decarboxylative coupling reactions. This new method uses a copper catalyst to transform simple carboxylic acids and arenes into heterobiaryls and haloalkyl arenes that are relevant to pharmaceutical and biological molecules. This technology offers improvements over classical coupling methods, including the replacement of expensive, toxic, and wasteful organometallic reagents with inexpensive and readily available carboxylic acid starting materials while generating minimal waste. The formation of C-C bonds are key steps in the construction of complex structures and the successful development of this methodology will enable the design of new, more efficient catalysts for the formation of C-C bonds by the pharmaceutical and fine chemical industries. Professor Hoover is actively engaged in the integration of research and education at the undergraduate level partly by involving undergraduates in the research laboratory and partly by incorporating research experiments and concepts into the undergraduate curriculum. This award also supports the development of a new summer program designed to bring together chemists, engineers, and artists to work toward the common goal of building a public science-art installation. The program is designed to initiate a meaningful dialog of science within the local Morgantown community, to help student participants communicate effectively between science, the humanities, and art, and with the broader public sphere.