IDBR: Type A: Ultrahigh-Speed Space-Division Multiplexing Optical Coherence Tomography for Label-free and Non-destructive Biological Imaging

IDBR：A 型：超高速空分复用光学相干断层扫描，用于无标记和无损生物成像

• 批准号: 1455613
• 负责人: Chao Zhou
• 金额: $ 51.02万
• 依托单位: Lehigh University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-05-15 至 2019-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1455613&HistoricalAwards=false
• 关键词: IDBR; Type; Ultrahigh; Speed; Space

An award is made to Lehigh University to develop an ultrahigh speed, label-free and non-destructive imaging technology based on optical coherence tomography (OCT) for biological research. The ability to non-invasively generate ultrafast, in vivo, 3D, synchronized structural and functional images of biological samples with micron-scale resolutions will greatly advance biological research. Technologies developed in this program can be readily transferred and disseminated to other fields, such as tissue engineering, ophthalmology and cancer imaging. In addition, the research project is integrated with multidisciplinary education and outreach activities to train graduate and undergraduate students to solve real-life problems, and to stimulate the interests of college and K-12 students in pursuing a career in science, technology, engineering and mathematics (STEM).The goal of the project is to develop further a space-division multiplexing OCT (SDM-OCT) technology in order to significantly improve OCT imaging speed through parallel imaging. This project will focus on developing new ultrafast functional imaging capabilities (e.g. Doppler) and optimized SDM components to facilitate broad dissemination. The utilities of SDM-OCT will be demonstrated in developmental biology/cardiology through collaboration at the Massachusetts General Hospital and Harvard Medical School. The SDM-OCT technology provides a new approach that can offer over an order of magnitude speed improvement for OCT without compromising image resolution and sensitivity. SDM-OCT also has favorable cost scalability, and allows synchronized cross-sectional and 3D imaging of intact tissue samples, enabling new biological applications.

里海大学获得了一项奖励，以开发一种基于光学相干断层扫描（OCT）的超高速、无标签和非破坏性成像技术，用于生物研究。无创生成微米级分辨率的超快速、活体、3D、同步生物样品结构和功能图像的能力将极大地推进生物学研究。在这个项目中开发的技术可以很容易地转移和传播到其他领域，如组织工程、眼科和癌症成像。此外，该研究项目与多学科教育和推广活动相结合，以培养研究生和本科生解决现实问题的能力，并激发大学和K-12学生追求科学、技术、工程和数学（STEM）职业生涯的兴趣。该项目的目标是进一步发展空分复用OCT （SDM-OCT）技术，以便通过并行成像显着提高OCT成像速度。该项目将重点开发新的超快功能成像能力（如多普勒）和优化的SDM组件，以促进广泛传播。通过麻省总医院和哈佛医学院的合作，SDM-OCT将在发育生物学/心脏病学中得到应用。SDM-OCT技术提供了一种新的方法，可以在不影响图像分辨率和灵敏度的情况下为OCT提供超过一个数量级的速度提高。SDM-OCT还具有良好的成本可扩展性，并允许完整组织样本的同步横截面和3D成像，从而实现新的生物学应用。

项目成果

Optical Coherence Tomography Detects Necrotic Regions and Volumetrically Quantifies Multicellular Tumor Spheroids.

• DOI: 10.1158/0008-5472.can-17-0821
• 发表时间: 2017-11-01
• 期刊: Cancer research
• 影响因子: 11.2
• 作者: Huang Y;Wang S;Guo Q;Kessel S;Rubinoff I;Chan LL;Li P;Liu Y;Qiu J;Zhou C
• 通讯作者: Zhou C

Wide-field high-speed space-division multiplexing optical coherence tomography using an integrated photonic device

• DOI: 10.1364/boe.8.003856
• 发表时间: 2017-08-01
• 期刊: BIOMEDICAL OPTICS EXPRESS
• 影响因子: 3.4
• 作者: Huang, Yongyang;Badar, Mudabbir;Zhou, Chao
• 通讯作者: Zhou, Chao

Longitudinal Morphological and Physiological Monitoring of Three-dimensional Tumor Spheroids Using Optical Coherence Tomography

• DOI: 10.3791/59020
• 发表时间: 2019-02-01
• 期刊: JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
• 影响因子: 1.2
• 作者: Huang，Yongyang;Zou，Jinyun;Zhou，Chao
• 通讯作者: Zhou，Chao