Genetic and immunologic basis of pathogenic and mutualistic interactions between bacteria and their ant hosts

细菌与其蚂蚁宿主之间致病和互利相互作用的遗传和免疫学基础

• 批准号: 218576263
• 负责人: Professor Dr. Roy Gross
• 金额: --
• 依托单位: Lehrstuhl für Mikrobiologie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2012
• 资助国家: 德国
• 起止时间: 2011-12-31 至 2015-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/218576263?language=en
• 关键词: Genetic; immunologic; basis; pathogenic; mutualistic

The project aims at elucidating basic features of the innate immune system of a social insect, the carpenter ant Camponotus floridanus. A special emphasis is placed on its mode of discrimination between pathogenic and beneficial bacteria, thereby avoiding the growth of harmful bacteria while allowing colonization by the essential obligate intracellular mutualist Blochmannia. Moreover, a possible role of the mutualists in the modulation of the immune response of the host will be investigated. Based on these experiments a major goal of this proposal is to generate a comprehensive model regarding the systems biology of the ant`s immune response.

该项目旨在阐明一种社会性昆虫-佛罗里达弓背蚁（Camponotus floridanus）的先天免疫系统的基本特征。一个特别强调的是放在它的模式之间的歧视致病菌和有益的细菌，从而避免有害细菌的生长，同时允许殖民化的必要的专性细胞内互利Blochmannia。此外，互利共生在宿主免疫反应的调制中可能发挥的作用将被研究。基于这些实验，该提案的主要目标是生成关于蚂蚁免疫反应的系统生物学的综合模型。

项目成果

Gene expression analysis of the endosymbiont-bearing midgut tissue during ontogeny of the carpenter ant Camponotus floridanus.

• DOI: 10.1016/j.jinsphys.2013.03.011
• 发表时间: 2013-06
• 期刊: Journal of insect physiology
• 影响因子: 2.2
• 作者: C. Ratzka;R. Gross;H. Feldhaar

Systemic gene knockdown in Camponotus floridanus workers by feeding of dsRNA

• DOI: 10.1007/s00040-013-0314-6
• 发表时间: 2013-08
• 期刊: Insectes Sociaux
• 影响因子: 1.3
• 作者: C. Ratzka;R. Gross;H. Feldhaar