Co-ordinate regulation of sugar, ethylene and hypoxia responses at the levels of transcription and metabolism by the SnRK1 kinase in Arabidopsis

拟南芥中 SnRK1 激酶在转录和代谢水平上协调糖、乙烯和缺氧反应

• 批准号: 218697737
• 负责人: Professor Dr. Peter Geigenberger
• 金额: --
• 依托单位: Max-Planck-Institut für Pflanzenzüchtungsforschung
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2012
• 资助国家: 德国
• 起止时间: 2011-12-31 至 2014-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/218697737?language=en
• 关键词: Co; ordinate; regulation; sugar; ethylene

AMP-activated protein kinases (AMPKs) play a central role in the regulation of carbon metabolism, energy homeostasis, sugar and stress signalling, and transcription in eukaryotes. Higher plant AMPK orthologs, named Snf1-related kinases (SnRK1), are proposed to perform analogous functions but so far little is know about their exact roles in modulation of metabolic, stress, hormonal and developmental pathways. The proposed collaborative project aims at joining expertise in physiological and metabolomics studies with genetic, biochemical and transcriptomics approaches in order to dissect precisely major functions of SnRK1 in cellular regulation. Ultimate goal of the project is to identify the mechanisms by which SnRK1 controls starch metabolism and stress responses to hypoxia, and to link these to emerging roles of SnRK1 in the control of genome-wide transcription and ethylene/sugar and ABA hormone signalling pathways.

腺苷酸活化蛋白激酶（AMPKs）在真核生物的碳代谢、能量平衡、糖和应激信号传导以及转录调控中起着重要作用。高等植物AMPK同源物，命名为Snf 1相关激酶（SnRK 1），被认为执行类似的功能，但到目前为止，很少有人知道它们在代谢，应激，激素和发育途径的调节中的确切作用。拟议的合作项目旨在将生理学和代谢组学研究的专业知识与遗传学，生物化学和转录组学方法结合起来，以精确剖析SnRK 1在细胞调控中的主要功能。该项目的最终目标是确定SnRK 1控制淀粉代谢和对缺氧的应激反应的机制，并将这些机制与SnRK 1在控制全基因组转录和乙烯/糖和阿坝激素信号通路中的新兴作用联系起来。