Structural and functional regulation of cell-cell junctions in diabetic retina

糖尿病视网膜细胞-细胞连接的结构和功能调节

• 批准号: 21910041
• 负责人: Professorin Dr. Carien Niessen, Ph.D.
• 金额: --
• 依托单位: Cluster of Excellence: Cellular Stress Responses in Aging-Associated Diseases
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2006
• 资助国家: 德国
• 起止时间: 2005-12-31 至 2009-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/21910041?language=en
• 关键词: Structural; functional; regulation; cell; junctions

Disturbance of the blood retina barrier due to vascular leakage is one of the early hallmarks of diabetic retinopathy. Since cell-cell junctions formed by adherens and tight junctions constitute a major part of the barrier formed by vascular endothelium and associated cells, we will address both structural and functional alterations in cellular junctions during the development of diabetic retinopathy. To obtain insight into the molecular basis of junctional dysfunction in diabetic retinopathy we also will examine in vivo how insulin and IGF signaling modulate adherens and tight junction function in endothelial cells and regulate vascular permeability. Overall, these studies will increase our understanding of the role of junctional activity in maintaining the blood retinal barrier and if aberrant regulation of junctions contributes the development of diabetic retinopathy.

由于血管渗漏引起的血视网膜屏障障碍是糖尿病视网膜病变的早期标志之一。由于粘附和紧密连接形成的细胞-细胞连接构成了血管内皮和相关细胞形成的屏障的主要部分，因此我们将解决糖尿病视网膜病变发展过程中细胞连接的结构和功能改变。为了深入了解糖尿病视网膜病变中连接功能障碍的分子基础，我们还将在体内研究胰岛素和IGF信号传导如何调节内皮细胞中的粘附和紧密连接功能以及调节血管通透性。总之，这些研究将增加我们对连接活性在维持血视网膜屏障中的作用的理解，以及连接的异常调节是否有助于糖尿病视网膜病变的发展。