RUI: New methods for chemical sialylation: an O-protecting group approach

RUI：化学唾液酸化的新方法：O-保护基方法

• 批准号: 1465003
• 负责人: Cristina De Meo
• 金额: $ 30万
• 依托单位: Southern Illinois University at Edwardsville
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-06-01 至 2019-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1465003&HistoricalAwards=false
• 关键词: RUI; New; methods; chemical; sialylation

In this project, funded by the Chemical Catalysis Program of the Chemistry Division, Professor Cristina DeMeo of the Southern Illinois University Edwardsville is investigating structural modifications of sialic acid derivatives. Sialic acids are carbohydrates which are involved in numerous biological phenomena, ranging from cell-cell adhesion and mobility to oncogenesis and recognition by viruses and bacteria. The broader impacts include advancing the chemistry of sialic acids, enabling access to important biologically active sialic acids, and training undergraduate and Master's students, with an emphasis on recruiting and training underrepresented minorities. Sialylations by chemical methods are often complicated by the intrinsic structural features of sialic acids, making the stereoselective synthesis of sialosides a challenge in carbohydrate chemistry. With the ultimate goal of gaining a better understanding of the roles of O-protecting groups in sialylations, this project is centered on the evaluation of sialyl donors functionalized at O-4 and O-7 positions. In addition, the research is addressing the influence of protecting groups at O-4 and N-5 on the conformation of sialic acids.

在这个项目中，由化学部的化学催化计划资助，南伊利诺伊大学爱德华兹维尔分校的Cristina DeMeo教授正在研究唾液酸衍生物的结构修饰。唾液酸是碳水化合物，其涉及许多生物现象，范围从细胞-细胞粘附和移动性到肿瘤发生和病毒和细菌的识别。更广泛的影响包括推进唾液酸的化学，使重要的生物活性唾液酸，并培训本科生和硕士生，重点是招聘和培训代表性不足的少数民族。 通过化学方法的唾液酸化通常由于唾液酸的固有结构特征而变得复杂，使得唾液酸苷的立体选择性合成成为碳水化合物化学中的挑战。为了更好地理解O-保护基团在唾液酸化中的作用，本项目的最终目标是评估O-4和O-7位官能化的唾液酸供体。此外，本研究还探讨了O-4和N-5位保护基对唾液酸构象的影响。