Catalytic Synthesis via C-C Cleavage

通过这一奖项，化学系的化学催化计划资助堪萨斯大学的Jon A.Tunge教授开发从普通碳-碳键获得活性中间体的策略，并利用这些活性中间体来应对合成中的挑战。这项工作的更广泛影响包括开发环境友好型催化合成。外展计划包括在Instagram上提供有机化学抽认卡，以及通过访问周末招募代表不足的学生。访问周末在堪萨斯大学对潜在的学生进行正在进行的化学教育，并培训学生申请研究生院的最佳实践。其中一个研究重点是通过脱羧基从廉价的羧酸中催化获得活性亲核剂和有机金属。目前的方法通常通过在高度碱性条件下形成化学计量比的有机金属或使用高能还原金属来获得相关的活性中间体。由于反应条件温和，所开发的脱羧化偶联剂比经典方法更环保，更适用于合成。通格教授还在开发直接在交叉偶联反应中使用酮的脱酰化偶联。

With this award, the Chemical Catalysis Program of the Chemistry Division is funding Professor Jon A. Tunge of the University of Kansas to develop strategies to access reactive intermediates from common carbon-carbon bonds and utilize those reactive intermediates to address challenges in synthesis. The broader impacts of the work include developing environmentally friendly catalytic synthesis. Outreach programs include providing organic chemistry flash cards on Instagram and recruiting underrepresented students through a visitation weekend. The visitation weekend educates prospective students on ongoing chemistry at the University of Kansas and trains the students on best practices for applying to graduate schools.One research focus is on catalytically accessing reactive nucleophiles and organometallics from inexpensive carboxylic acids via decarboxylation. Current methods typically access related reactive intermediates through formation of stoichiometric organometallics under highly basic conditions or using high energy reduced metals. The decarboxylative couplings developed are more environmentally benign than classic methods and are more applicable in synthesis due to the mild reaction conditions. Professor Tunge is also developing deacylative couplings that directly employ ketones in cross-coupling reactions.