On the trail of the first venomous crustacean: venom gland transcriptome profiling of Remipedia (Crustacea)

追踪第一种有毒甲壳类动物：甲壳纲（甲壳类）毒液腺转录组分析

• 批准号: 220551938
• 负责人: Dr. Björn Marcus von Reumont
• 金额: --
• 依托单位: Department of Zoology
• 依托单位国家: 德国
• 项目类别: Research Fellowships
• 财政年份: 2012
• 资助国家: 德国
• 起止时间: 2011-12-31 至 2013-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/220551938?language=en
• 关键词: trail; first; venomous; crustacean; venom

Venomous animals are ubiquitous in aquatic and terrestrial habitats across the world. The widespread convergent evolution of venoms in the animal kingdom is testament to their importance as key ecological adaptations. Venomics - the scientific study of venoms - is still in its relative infancy because comprehensive venom composition profiles have been generated primarily for a narrow range of species. A more complete understanding of fundamental issues about the biology and evolution of venoms and venomous organisms requires a broader perspective. The most obvious avenue for progress is the investigation of taxa that are suspected to be venomous, especially if they are distantly related to other venomous species.In this respect remipede crustaceans are an extraordinarily promising group, as Crustacea is the only major traditional arthropod group without known venomous species. Recent studies show that Remipedia are the possible sistergroup to Hexapoda supporting Pancrustacea instead of the traditional Atelocerata (= Tracheata) concept.The specific questions and general approach in this project are: 1. What putative toxin families are expressed in the suspected venom glands of remipedes?2. How does remipede venom composition compare with that of other venomous arthropods and non-arthropods?These questions will be addressed with next generation sequencing technology to generate the first crustacean venom gland profile. The resulting dataset will provide a unique resource for analyses in comparative venomics.

有毒动物在世界各地的水生和陆生栖息地中无处不在。毒液在动物界的广泛趋同进化证明了它们作为关键生态适应的重要性。毒液组学-对毒液的科学研究-仍处于相对初级阶段，因为主要是为范围很窄的物种生成了全面的毒液成分谱。要更全面地了解毒液和有毒生物的生物学和进化的基本问题，需要更广阔的视野。最明显的进步途径是调查那些被怀疑有毒的类群，特别是如果它们与其他有毒物种有远亲关系。在这方面，remipede甲壳类是一个非常有前途的群体，因为甲壳纲是唯一没有已知有毒物种的主要传统节肢动物群体。最近的研究表明，Remipedia可能是六足纲的姐妹类群，支持Pancrustacea而不是传统的Atelocerata（= Tracheata）概念。 在疑似的remipedes毒腺中表达的毒素家族是什么？2. 与其他有毒节肢动物和非节肢动物的毒液成分相比，蹄足类的毒液成分如何？这些问题将通过下一代测序技术来解决，以产生第一个甲壳类动物毒腺图谱。由此产生的数据集将提供一个独特的资源比较静脉组学的分析。