Catch and Release of Small Molecules With Porous Nanocapsules

用多孔纳米胶囊捕获和释放小分子

• 批准号: 1522525
• 负责人: Evgueni Pinkhassik
• 金额: $ 6.03万
• 依托单位: University of Connecticut
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-12-15 至 2015-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1522525&HistoricalAwards=false
• 关键词: Catch; Release; Small; Molecules; Porous

The ability to control the transport of small molecules through very small pores in membranes is important for a variety of applications such as the development of drug delivery systems and separation techniques. An improved understanding of the fundamental chemistry that controls the transport of small molecules would have broad biomedical, biotechnology, and environmental implications. The Macromolecular, Supramolecular and Nanochemistry (MSN) Program supports the work of Professor Eugene Pinkhassik of the University of Connecticut focusing on regulating the transport of small molecules through gated nanopores and creating nanocapsules capable of rapid uptake and release of small molecules. The transport will be regulated by controlling the chemical environment of nanopores and by reversible binding of plugs or lids. This interdisciplinary project integrates research and training with outreach activities aimed at underrepresented groups in science and engineering.

控制小分子通过膜中非常小的孔的传输的能力对于药物输送系统和分离技术的开发等各种应用是重要的。更好地理解控制小分子运输的基础化学将具有广泛的生物医学、生物技术和环境影响。大分子、超分子和纳米化学(MSN)计划支持康涅狄格大学Eugene Pinkhassik教授的工作，重点是调节小分子通过门控纳米孔的运输，并创建能够快速吸收和释放小分子的纳米胶囊。运输将通过控制纳米孔的化学环境和可逆的塞子或盖子的结合来调节。这一跨学科项目将研究和培训与针对科学和工程领域代表性不足群体的外联活动结合在一起。

项目成果

Evidence for diffusing atomic oxygen uncovered by separating reactants with a semi-permeable nanocapsule barrier

• DOI: 10.1039/c8cc06715e
• 发表时间: 2019-02-11
• 期刊: CHEMICAL COMMUNICATIONS
• 影响因子: 4.9
• 作者: Omlid, Sara M.;Dergunov, Sergey A.;McCulla, Ryan D.
• 通讯作者: McCulla, Ryan D.